<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2011-04-04</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000771856</issuerCik>
        <issuerName>CHAMPIONS ONCOLOGY, INC.</issuerName>
        <issuerTradingSymbol>CSBR.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001485934</rptOwnerCik>
            <rptOwnerName>Battery Ventures IX, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>930 WINTER STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 2500</rptOwnerStreet2>
            <rptOwnerCity>WALTHAM</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02451</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001517640</rptOwnerCik>
            <rptOwnerName>Battery Investment Partners IX, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>930 WINTER STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 2500</rptOwnerStreet2>
            <rptOwnerCity>WALTHAM</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02451</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001517642</rptOwnerCik>
            <rptOwnerName>Battery Partners IX, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>930 WINTER STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 2500</rptOwnerStreet2>
            <rptOwnerCity>WALTHAM</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02451</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>5466667</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Funds</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Warrant to purchase shares of Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.90</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2011-04-04</value>
            </exerciseDate>
            <expirationDate>
                <value>2016-04-04</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>820000</value>
                    <footnoteId id="F2"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Funds</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Consists of 5,412,547 shares of the Issuer's Common Stock held by Battery Ventures IX, L.P. (&quot;BVIX&quot;) and 54,120 shares of the Issuer's Common Stock held by Battery Investment Partners IX, LLC (&quot;BIPIX&quot;). BVIX and BIPIX are under common control, as Battery Partners IX, LLC (&quot;BPIX&quot;) is the sole general partner of BVIX and the sole manager of BIPIX.  BVIX, BIPIX and BPIX expressly disclaim beneficial ownership over all shares held by BVIX, BIPIX and BPIX, except to the extent of their indirect pecuniary interest therein.</footnote>
        <footnote id="F2">The number of shares of common stock issuable upon the exercise of the warrant is subject to certain adjustments for dividends, combinations of stock, reorganizations or mergers or similar transactions pursuant to the terms of the warrant.</footnote>
        <footnote id="F3">Consists of a warrant to purchase 811,882 shares of the Issuer's Common Stock held by BVIX and a warrant to purchase 8,118 shares of the Issuer's Common Stock held by BIPIX.  BVIX and BIPIX are under common control, as BPIX is the sole general partner of BVIX and the sole manager of BIPIX.  BVIX, BIPIX and BPIX expressly disclaim beneficial ownership over all shares held by BVIX, BIPIX and BPIX, except to the extent of their indirect pecuniary interest therein.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Christopher Schiavo By: Christopher Schiavo  (acting as attorney-in-fact on behalf of Battery Ventures IX, L.P.)</signatureName>
        <signatureDate>2011-04-14</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Christopher Schiavo By: Christopher Schiavo  (acting as attorney-in-fact on behalf of Battery Investment Partners IX, LLC)</signatureName>
        <signatureDate>2011-04-14</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Christopher Schiavo By: Christopher Schiavo (acting as attorney-in-fact on behalf of Battery Partners IX, LLC)</signatureName>
        <signatureDate>2011-04-14</signatureDate>
    </ownerSignature>
</ownershipDocument>
