Accrued Expenses (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
Product revenue allowances	$ 26,236	$ 26,624
Accrued clinical	16,710	14,036
Collaborative arrangement accrued liability	28,019	22,654
Accrued payroll and related	7,130	15,863
Lease liability	$ 4,763	$ 4,802
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]	Total accrued expenses	Total accrued expenses
Royalties	$ 3,175	$ 3,472
Professional fees	2,711	1,899
Accrued commercial manufacturing	3,884	3,843
Accrued other	17,032	11,263
Total accrued expenses	$ 109,660	$ 104,456