License, Collaboration and Other Significant Agreements - Sublicense Agreement with Japan Tobacco, Inc. and its subsidiary, Torii Pharmaceutical Co., Ltd. (Details) $ in Thousands	3 Months Ended
Mar. 31, 2022 USD ($) performance_obligation	Mar. 31, 2021 USD ($)
License, Collaboration and Other Revenue:
Recognized revenue	$ 61,699	$ 52,304
JT and Torii \| Sublicense Agreement
License, Collaboration and Other Revenue:
Number of performance obligations \| performance_obligation	2
Recognized revenue	$ 1,100	$ 1,200

Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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+ Details