Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Revenues:
Total revenues	$ 61,699	$ 52,304
Cost of goods sold:
Product	22,333	25,595
Amortization of intangibles	9,011	9,011
Total cost of goods sold	31,344	34,606
Operating expenses:
Research and development	43,833	40,611
Selling, general and administrative	44,327	41,328
License expense	688	695
Total operating expenses	88,848	82,634
Operating loss	(58,493)	(64,936)
Other income (expense):
Interest expense	(5,062)	(4,805)
Other income	1,134	161
Net loss	$ (62,421)	$ (69,580)
Net loss per share - basic (in dollars per share)	$ (0.35)	$ (0.45)
Net loss per share - diluted (in dollars per share)	$ (0.35)	$ (0.45)
Weighted-average number of common shares - basic (in shares)	179,599,045	153,820,809
Weighted-average number of common shares - diluted (in shares)	179,599,045	153,820,809
Comprehensive loss:
Net loss	$ (62,421)	$ (69,580)
Other comprehensive loss - unrealized loss on debt securities	0	(4)
Total comprehensive loss	(62,421)	(69,584)
Product revenue, net
Revenues:
Total revenues	41,448	30,408
License, collaboration and other revenue
Revenues:
Total revenues	$ 20,251	$ 21,896