License, Collaboration and Other Significant Agreements - Revenues Recognized From License, Collaboration and Other Significant Agreements (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
License, Collaboration and Other Revenue:
Total revenues	$ 61,699	$ 52,304
Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
Total revenues	1,600
License, collaboration and other revenue
License, Collaboration and Other Revenue:
Total revenues	20,251	21,896
License, collaboration and other revenue | Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
Total revenues	7,962	18
License, collaboration and other revenue | Otsuka Pharmaceutical Company. Ltd. | Otsuka U.S. Agreement
License, Collaboration and Other Revenue:
Total revenues	5,638	13,674
License, collaboration and other revenue | Otsuka Pharmaceutical Company. Ltd. | Otsuka International Agreement
License, Collaboration and Other Revenue:
Total revenues	5,503	6,972
License, collaboration and other revenue | Total Proportional Performance Revenue
License, Collaboration and Other Revenue:
Total revenues	19,103	20,664
License, collaboration and other revenue | JT and Torii
License, Collaboration and Other Revenue:
Total revenues	1,148	1,159
License, collaboration and other revenue | MTPC Other Revenue | Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
Total revenues	$ 0	$ 73