Net Loss per Share (Tables)

12 Months Ended

Dec. 31, 2015

Calculation of Basic and Diluted Net Loss per Share

The following table presents the calculation of basic and diluted net loss per share applicable to common stockholders:


	Year ended December 31,
	2015			2014
	(in thousands, except share and per share data)
Numerator:
Net loss	$	(60,716	)	$	(37,034	)
Accretion on preferred stock		—			(86,899	)
Net loss applicable to common stockholders	$	(60,716	)	$	(123,933	)

Denominator:
Weighted-average number of common shares – basic and diluted		26,469,170			15,406,386
Net loss per share applicable to common stockholders – basic and diluted	$	(2.29	)	$	(8.04	)

Anti-Dilutive Securities Excluded from Calculation of Diluted Net Loss per Share

The amounts in the table below were excluded from the calculation of diluted net loss per share, prior to the use of the treasury stock method, due to their anti-dilutive effect:

	Year ended December 31,
	2015		2014
Outstanding stock options		2,206,635		1,526,346
Unvested restricted stock		216,716		422,145
Unvested restricted stock units		24,425		—
Total		2,447,776		1,948,491