<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2010-11-23</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001475899</issuerCik>
        <issuerName>NYTEX Energy Holdings, Inc.</issuerName>
        <issuerTradingSymbol>NYTE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001517004</rptOwnerCik>
            <rptOwnerName>Francis Michael G</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1222 MERIT DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1850</rptOwnerStreet2>
            <rptOwnerCity>DALLAS</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>75251</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2822063</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">On November 23, 2010, NYTEX Energy Holdings, Inc. (the &quot;Company&quot;) issued 2,822,063 shares of Common Stock to Mr. Michael G. Francis in connection with the Company's acquisition of Francis Drilling Fluids, Ltd. (&quot;FDF&quot;)</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/S/ Michael G. Francis</signatureName>
        <signatureDate>2011-03-29</signatureDate>
    </ownerSignature>
</ownershipDocument>
