X0306 4 2020-10-30 0 0001515673 Ultragenyx Pharmaceutical Inc. RARE 0001677455 Parschauer Karah Herdman C/O ULTRAGENYX PHARMACEUTICAL INC. 60 LEVERONI COURT NOVATO CA 94949 0 1 0 0 EVP and General Counsel Common Stock 2020-10-30 4 M 0 9903 54.50 A 33871 D Common Stock 2020-10-30 4 S 0 9903 100.12 D 24061 D Stock Option (Right to Buy) 54.50 2020-10-30 4 M 0 9903 0.00 D 2026-06-20 Common Stock 9903 25000 D The transactions reported on this Form 4 were effected pursuant to a trading plan adopted by the Reporting Person pursuant to Rule 10b5-1 under the Securities Exchange Act of 1934, as amended. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $100.00 to $100.20 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions. Includes 93 shares acquired under the Company's 2014 Employee Stock Purchase Plan on October 31, 2020. The option vested with respect to 1/4th of the shares on June 20, 2017 (the first anniversary of the grant date of the option or the "Option Anniversary Date") and 1/48th of the shares initially subject to the option continued to vest on each month as measured from the Option Anniversary Date such that the option fully vested on the fourth anniversary of the grant date. /s/ Karah Parschauer 2020-11-02