X0306 4/A 2018-08-21 2018-08-21 0 0001515673 Ultragenyx Pharmaceutical Inc. RARE 0001677455 Parschauer Karah Herdman C/O ULTRAGENYX PHARMACEUTICAL INC. 60 LEVERONI COURT NOVATO CA 94949 0 1 0 0 EVP and General Counsel Common Stock 2018-08-21 4 M 0 5000 54.50 A 19181 D Common Stock 2018-08-21 4 S 0 5000 78.53 D 14181 D Stock Option (Right to Buy) 54.50 2018-08-21 4 M 0 5000 0.00 D 2026-06-20 Common Stock 5000 55000 D The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $78.43 to $78.63 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions. 1/4th of the option vested on June 20, 2017 and 1/48th of the option vests monthly thereafter. This amendment is filed to report the exercise of 5000 previously awarded stock options that was part of the same day sale reported on August 21, 2018 and to correct the direct holdings reported therein. No other changes were made to the information reported on the original Form 4 filed on August 21, 2018. /s/ Ruben A. Garcia, attorney-in-fact 2018-10-09