CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Operating activities:
Net loss	$ (310,482)	$ (258,569)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation	65,260	51,345
Amortization of premium on marketable debt securities, net	3,380	2,511
Depreciation and amortization	8,569	6,488
Change in fair value of equity investments	19,513	51,665
Non-cash collaboration royalty revenue	(10,261)	(8,561)
Non-cash interest expense on liability related to the sale of future royalties	12,636	16,935
Other	386	511
Changes in operating assets and liabilities:
Accounts receivable	(8,902)	(1,669)
Inventory	(4,705)	(2,174)
Prepaid expenses and other assets	(6,793)	(9,002)
Accounts payable, accrued, and other liabilities	41,260	(11,526)
Contract liabilities	(4,639)	(62,656)
Net cash used in operating activities	(194,778)	(224,702)
Investing activities:
Purchase of property, plant, and equipment	(63,107)	(36,485)
Purchase of marketable debt securities	(205,278)	(664,347)
Proceeds from sale of marketable debt securities	42,950	70,548
Proceeds from maturities of marketable debt securities	297,304	406,614
Payment for intangible asset	(30,000)
Other	(63)
Net cash provided by (used in) investing activities	41,806	(223,670)
Financing activities:
Proceeds from the issuance of common stock equity plan awards, net	7,738	25,503
Other	(289)	(226)
Net cash provided by financing activities	7,449	25,277
Effect of exchange rate changes on cash	(1,346)	(323)
Net decrease in cash, cash equivalents and restricted cash	(146,869)	(423,418)
Cash, cash equivalents and restricted cash at beginning of period	309,585	726,294
Cash, cash equivalents and restricted cash at end of period	162,716	302,876
Supplemental disclosures of non-cash information:
Acquired lease liabilities arising from obtaining right-of-use assets	1,036	$ 2,301
Non-cash interest expense on liability related to the sale of future royalties capitalized into ending property, plant and equipment	$ 4,781