CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenues:
Total revenues	$ 89,343	$ 86,975	$ 169,278	$ 186,370
Operating expenses:
Cost of sales	8,270	3,136	14,370	8,324
Research and development	154,529	113,205	297,684	260,723
Selling, general and administrative	68,137	53,410	135,449	106,668
Total operating expenses	230,936	169,751	447,503	375,715
Loss from operations	(141,593)	(82,776)	(278,225)	(189,345)
Interest income	899	441	1,393	1,080
Change in fair value of equity investments	(10,184)	(31,046)	(19,513)	(51,665)
Non-cash interest expense on liability related to the sale of future royalties	(6,052)	(8,517)	(12,636)	(16,935)
Other expense	(930)	(67)	(641)	(862)
Loss before income taxes	(157,860)	(121,965)	(309,622)	(257,727)
Provision for income taxes	(302)	(463)	(860)	(842)
Net loss	$ (158,162)	$ (122,428)	$ (310,482)	$ (258,569)
Net loss per share, basic and diluted	$ (2.26)	$ (1.81)	$ (4.45)	$ (3.84)
Weighted-average shares used in computing net loss per share, basic and diluted	69,925,358	67,607,752	69,722,141	67,356,443
Collaboration and License
Revenues:
Total revenues	$ 53,088	$ 63,940	$ 101,501	$ 142,950
Product Sales
Revenues:
Total revenues	30,832	18,346	57,516	34,859
Non-cash Collaboration Royalty Revenue
Revenues:
Total revenues	$ 5,423	$ 4,689	$ 10,261	$ 8,561