<?xml version="1.0" ?>
<informationTable xsi:schemaLocation="http://www.sec.gov/edgar/document/thirteenf/informationtable eis_13FDocument.xsd" xmlns="http://www.sec.gov/edgar/document/thirteenf/informationtable" xmlns:n1="http://www.sec.gov/edgar/document/thirteenf/informationtable" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <infoTable>
    <nameOfIssuer>AGIOS PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>00847X104</cusip>
    <value>4410130</value>
    <shrsOrPrnAmt>
      <sshPrnamt>162018</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>162018</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>ALKERMES PLC</nameOfIssuer>
    <titleOfClass>SHS</titleOfClass>
    <cusip>G01767105</cusip>
    <value>3949993</value>
    <shrsOrPrnAmt>
      <sshPrnamt>141172</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>141172</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>AMICUS THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>03152W109</cusip>
    <value>3713379</value>
    <shrsOrPrnAmt>
      <sshPrnamt>260771</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>260771</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>AMYLYX PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>03237H101</cusip>
    <value>3295762</value>
    <shrsOrPrnAmt>
      <sshPrnamt>272828</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>272828</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>ANNEXON INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>03589W102</cusip>
    <value>10202924</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2032455</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>2032455</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>ARROWHEAD PHARMACEUTICALS IN</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>04280A100</cusip>
    <value>6435515</value>
    <shrsOrPrnAmt>
      <sshPrnamt>96935</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>96935</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>AUTOLUS THERAPEUTICS PLC</nameOfIssuer>
    <titleOfClass>SPON ADS</titleOfClass>
    <cusip>05280R100</cusip>
    <value>18905000</value>
    <shrsOrPrnAmt>
      <sshPrnamt>9500000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>9500000</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>AVADEL PHARMACEUTICALS PLC</nameOfIssuer>
    <titleOfClass>COM SHS</titleOfClass>
    <cusip>G29687103</cusip>
    <value>943093</value>
    <shrsOrPrnAmt>
      <sshPrnamt>43763</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>43763</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>AXSOME THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>05464T104</cusip>
    <value>4919226</value>
    <shrsOrPrnAmt>
      <sshPrnamt>26934</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>26934</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>CELLDEX THERAPEUTICS INC NEW</nameOfIssuer>
    <titleOfClass>COM NEW</titleOfClass>
    <cusip>15117B202</cusip>
    <value>6621608</value>
    <shrsOrPrnAmt>
      <sshPrnamt>243800</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>243800</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>DYNE THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>26818M108</cusip>
    <value>4850821</value>
    <shrsOrPrnAmt>
      <sshPrnamt>247997</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>247997</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>HARMONY BIOSCIENCES HLDGS IN</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>413197104</cusip>
    <value>3099274</value>
    <shrsOrPrnAmt>
      <sshPrnamt>82824</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>82824</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>IMMUNOVANT INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>45258J102</cusip>
    <value>4224474</value>
    <shrsOrPrnAmt>
      <sshPrnamt>166187</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>166187</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>KOLIBRI GLOBAL ENERGY INC</nameOfIssuer>
    <titleOfClass>COM NEW</titleOfClass>
    <cusip>50043K406</cusip>
    <value>16721969</value>
    <shrsOrPrnAmt>
      <sshPrnamt>4254954</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <otherManager>1,2,3</otherManager>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>4254954</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>KOLIBRI GLOBAL ENERGY INC</nameOfIssuer>
    <titleOfClass>COM NEW</titleOfClass>
    <cusip>50043K406</cusip>
    <value>10530632</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2679550</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <otherManager>1,2</otherManager>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>2679550</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>KRYSTAL BIOTECH INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>501147102</cusip>
    <value>2912624</value>
    <shrsOrPrnAmt>
      <sshPrnamt>11814</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>11814</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>LYFT INC</nameOfIssuer>
    <titleOfClass>CL A COM</titleOfClass>
    <cusip>55087P104</cusip>
    <value>19370000</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1000000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>1000000</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>MAPLIGHT THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>56565P103</cusip>
    <value>2889882</value>
    <shrsOrPrnAmt>
      <sshPrnamt>164525</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>164525</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>MBX BIOSCIENCES INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>55287L101</cusip>
    <value>4520534</value>
    <shrsOrPrnAmt>
      <sshPrnamt>143327</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>143327</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>NEKTAR THERAPEUTICS</nameOfIssuer>
    <titleOfClass>COM NEW</titleOfClass>
    <cusip>640268306</cusip>
    <value>2929454</value>
    <shrsOrPrnAmt>
      <sshPrnamt>69287</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>69287</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>PHARVARIS N V</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>N69605108</cusip>
    <value>5400483</value>
    <shrsOrPrnAmt>
      <sshPrnamt>194612</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>194612</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>PRAXIS PRECISION MEDICINES I</nameOfIssuer>
    <titleOfClass>COM NEW</titleOfClass>
    <cusip>74006W207</cusip>
    <value>6764872</value>
    <shrsOrPrnAmt>
      <sshPrnamt>22952</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>22952</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>RAPT THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM NEW</titleOfClass>
    <cusip>75382E208</cusip>
    <value>4463050</value>
    <shrsOrPrnAmt>
      <sshPrnamt>131770</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>131770</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>SILENCE THERAPEUTICS PLC</nameOfIssuer>
    <titleOfClass>ADS</titleOfClass>
    <cusip>82686Q101</cusip>
    <value>2221444</value>
    <shrsOrPrnAmt>
      <sshPrnamt>365369</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>365369</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>SNOWFLAKE INC</nameOfIssuer>
    <titleOfClass>COM SHS</titleOfClass>
    <cusip>833445109</cusip>
    <value>2193600</value>
    <shrsOrPrnAmt>
      <sshPrnamt>10000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>10000</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>SPRINKLR INC</nameOfIssuer>
    <titleOfClass>CL A</titleOfClass>
    <cusip>85208T107</cusip>
    <value>17116000</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2200000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <otherManager>1,2,3</otherManager>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>2200000</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>UIPATH INC</nameOfIssuer>
    <titleOfClass>CL A</titleOfClass>
    <cusip>90364P105</cusip>
    <value>67724201</value>
    <shrsOrPrnAmt>
      <sshPrnamt>4132044</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <otherManager>1,2,3</otherManager>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>4132044</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>UIPATH INC</nameOfIssuer>
    <titleOfClass>CL A</titleOfClass>
    <cusip>90364P105</cusip>
    <value>171275500</value>
    <shrsOrPrnAmt>
      <sshPrnamt>10450000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>10450000</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>UIPATH INC</nameOfIssuer>
    <titleOfClass>CL A</titleOfClass>
    <cusip>90364P105</cusip>
    <value>47005799</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2867956</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <otherManager>1,2</otherManager>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>2867956</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>WORKIVA INC</nameOfIssuer>
    <titleOfClass>COM CL A</titleOfClass>
    <cusip>98139A105</cusip>
    <value>12937500</value>
    <shrsOrPrnAmt>
      <sshPrnamt>150000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <otherManager>1,2,3</otherManager>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>150000</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>ZEVRA THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM NEW</titleOfClass>
    <cusip>488445206</cusip>
    <value>1724961</value>
    <shrsOrPrnAmt>
      <sshPrnamt>192518</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>DFND</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>192518</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
</informationTable>
