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  <headerData>
    <submissionType>13F-HR/A</submissionType>
    <filerInfo>
      <liveTestFlag>LIVE</liveTestFlag>
      <flags/>
      <filer>
        <credentials>
          <cik>0001514334</cik>
          <ccc>XXXXXXXX</ccc>
        </credentials>
      </filer>
      <periodOfReport>06-30-2022</periodOfReport>
    </filerInfo>
  </headerData>
  <formData>
    <coverPage>
      <reportCalendarOrQuarter>06-30-2022</reportCalendarOrQuarter>
      <isAmendment>true</isAmendment>
      <amendmentNo>1</amendmentNo>
      <amendmentInfo>
        <amendmentType>RESTATEMENT</amendmentType>
        <confDeniedExpired>false</confDeniedExpired>
      </amendmentInfo>
      <filingManager>
        <name>MSD Partners, L.P.</name>
        <address>
          <ns1:street1>One Vanderbilt Avenue, 26th Floor</ns1:street1>
          <ns1:city>New York</ns1:city>
          <ns1:stateOrCountry>NY</ns1:stateOrCountry>
          <ns1:zipCode>10017</ns1:zipCode>
        </address>
      </filingManager>
      <reportType>13F HOLDINGS REPORT</reportType>
      <form13FFileNumber>028-14878</form13FFileNumber>
      <crdNumber>000161664</crdNumber>
      <secFileNumber>801-74071</secFileNumber>
      <provideInfoForInstruction5>Y</provideInfoForInstruction5>
      <additionalInformation>This Amendment No. 1 to Form 13F for the quarter ended June 30, 2022, originally filed with the Securities and Exchange Commission on August 15, 2022, is being filed for the purpose of is being filed for the purpose of (i) revising the number of shares previously reported for an equity position, and (ii) including additional reportable positions that were previously omitted.With respect to those reportable positions that were included in the original filing and are included in this Amendment No. 1 without revision, the Column 4 values reported in the Information Table of this Amendment No. 1 reflect the originally reported values of such positions as multiplied by 1,000 to comply with current Form 13F reporting requirements. We note that the previously reported values of such positions were consistent with the Form 13F reporting requirements (requiring values rounded to the nearest thousandth) applicable at the time of the original filing.</additionalInformation>
    </coverPage>
    <signatureBlock>
      <name>Robert K. Simonds</name>
      <title>Partner and Chief Compliance Officer</title>
      <phone>(212) 303-4728</phone>
      <signature>/s/ Robert K. Simonds</signature>
      <city>New York</city>
      <stateOrCountry>NY</stateOrCountry>
      <signatureDate>06-22-2023</signatureDate>
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      <tableEntryTotal>93</tableEntryTotal>
      <tableValueTotal>1620836077</tableValueTotal>
      <isConfidentialOmitted>false</isConfidentialOmitted>
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