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Summary of Significant Accounting Policies - Additional Information (Detail)		1 Months Ended		2 Months Ended	3 Months Ended	6 Months Ended	9 Months Ended	12 Months Ended
	Oct. 12, 2018 USD ($)	Feb. 28, 2019 USD ($)	Jul. 31, 2016 USD ($)	Nov. 30, 2016 USD ($)	Mar. 31, 2018 USD ($)	Jun. 30, 2018 USD ($)	Sep. 30, 2018 USD ($)	Dec. 31, 2018 USD ($) Segment	Dec. 31, 2017 USD ($)
Significant Accounting Policies [Line Items]
Accumulated deficit								$ (450,565,000)	$ (374,232,000)
Working capital								56,100,000
Cash and cash equivalents								56,992,000	81,146,000
Proceeds from issuance of common stock in follow-on offering, net of issuance costs				$ 59,100,000				$ 52,000	2,968,000
Decreased in investing activities					$ 1,500,000	$ 1,900,000	$ 1,900,000
Increased in financing activities					$ 1,500,000	$ 1,900,000	$ 1,900,000
Number of operating segment \| Segment								1
Cash and cash equivalents, restricted cash maturity period								Three months or less
Impairments of long-lived assets								$ 0	0
Estimated useful life of intangible assets								2 years 6 months
Revenue from product development award								$ 1,371,000	40,000,000
Reclassification of Restricted Cash to Cash and Cash Equivalents [Member] \| ASU-2016-18 [Member]
Significant Accounting Policies [Line Items]
Reclassification of restricted cash								2,400,000
Cancer Prevention & Research Institute of Texas [Member]
Significant Accounting Policies [Line Items]
Revenue from product development award			$ 20,000,000
Teijin Limited [Member]
Significant Accounting Policies [Line Items]
Contract revenues received									$ 40,000,000
Grant Revenue [Member]
Significant Accounting Policies [Line Items]
Revenue from product development award								1,371,000
Grant Revenue [Member] \| Cancer Prevention & Research Institute of Texas [Member] \| Aravive Biologics [Member]
Significant Accounting Policies [Line Items]
Revenue from product development award	$ 15,400,000
Deferred Revenue								$ 100,000
Grant Revenue [Member] \| Cancer Prevention & Research Institute of Texas [Member] \| Aravive Biologics [Member] \| Subsequent Event [Member]
Significant Accounting Policies [Line Items]
Revenue from product development award		$ 2,600,000
Assembled Workforce [Member]
Significant Accounting Policies [Line Items]
Estimated useful life of intangible assets								3 years
Minimum [Member]
Significant Accounting Policies [Line Items]
Property and equipment estimated useful lives								3 years
Maximum [Member]
Significant Accounting Policies [Line Items]
Property and equipment estimated useful lives								5 years
Percentage for the amount of benefit realized upon ultimate settlement								50.00%