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Restructuring Plan - Additional Information (Detail) - Restructuring Plan [Member]
$ in Millions
1 Months Ended 6 Months Ended
Jun. 26, 2018
Employee
Oct. 31, 2017
Jun. 30, 2018
USD ($)
Restructuring Cost And Reserve [Line Items]      
Restructuring plan effective date   Oct. 20, 2017  
Total number of employees reduced | Employee 14    
Approximate reduction as a percent of workforce 59.00%    
Restructuring plan notification date to affected employees Jun. 26, 2018    
One-time severance-related charge     $ 3.5
General and administrative [Member]      
Restructuring Cost And Reserve [Line Items]      
One-time severance-related charge     1.2
Research and development [Member]      
Restructuring Cost And Reserve [Line Items]      
One-time severance-related charge     $ 2.3