Summary of Significant Accounting Policies (Tables)

3 Months Ended

Mar. 31, 2018

Schedule of Estimated Stock-Based Compensation Expense

Stock-based compensation expense, net of estimated forfeitures, is reflected in the condensed consolidated statements of operations and comprehensive loss as follows (in thousands):

	Three Months Ended
	March 31,
	2018		2017
Operating Expenses
Research and development	$	882	$	1,481
General and administrative		1,938		2,383
Total	$	2,820	$	3,864

Reconciliation of Captions in Consolidated Balance Sheet to Consolidated Statements of Cash Flows

The following is a reconciliation of the captions in the consolidated balance sheet to the consolidated statements of cash flows (in thousands):

	As of
	March 31, 2018		December 31, 2017		March 31, 2017		December 31, 2016
Consolidated Balance Sheets
Cash and cash equivalents	$	74,686	$	81,146	$	165,081	$	201,153
Restricted cash (included in other current assets)		2,386		2,383		2,378		—
Cash, cash equivalents and restricted cash in Consolidated Statements of Cash Flows	$	77,072	$	83,529	$	167,459	$	201,153