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Income Taxes - Significant Components of Net Deferred Tax Assets (Detail) - USD ($)
$ in Thousands
Dec. 31, 2016
Dec. 31, 2015
Income Tax Disclosure [Abstract]    
Net operating loss carry forwards $ 32,500 $ 33,684
Research and development tax credits 8,142 4,982
Stock based compensation and other 7,256 4,465
Depreciation and amortization 78 42
Total deferred tax assets 47,976 43,173
Less: Valuation allowance $ (47,976) $ (43,173)