Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Direct Offering [Member] Common Stock [Member]	Direct Offering [Member] Additional Paid-in Capital [Member]	Direct Offering [Member] Retained Earnings [Member]	Direct Offering [Member]	At-the-market Offering [Member] Common Stock [Member]	At-the-market Offering [Member] Additional Paid-in Capital [Member]	At-the-market Offering [Member] Retained Earnings [Member]	At-the-market Offering [Member]	Registered Direct Offering [Member] Common Stock [Member]	Registered Direct Offering [Member] Additional Paid-in Capital [Member]	Registered Direct Offering [Member] Retained Earnings [Member]	Registered Direct Offering [Member]	Private Placement [Member] Common Stock [Member]	Private Placement [Member] Additional Paid-in Capital [Member]	Private Placement [Member] Retained Earnings [Member]	Private Placement [Member]	Common Stock [Member]	Additional Paid-in Capital [Member]	Retained Earnings [Member]	Total
Balance (in shares) at Dec. 31, 2020																	16,481,099
Balance at Dec. 31, 2020																	$ 2	$ 548,707	$ (500,654)	$ 48,055
Issuance of common stock upon exercise of options (in shares)																	219,109
Issuance of common stock upon exercise of options																	$ 0	308	0	308
Issuance of common stock under employee benefit plans (in shares)																	31,759
Issuance of common stock under employee benefit plans																	$ 0	120	0	120
Issuance of common stock, net (in shares)	2,875,000				1,432,627
Issuance of common stock, net	$ 0	$ 20,866	$ 0	$ 20,866	$ 0	$ 9,767	$ 0	$ 9,767
Stock-based compensation																	0	2,257	0	2,257
Net loss																	$ 0	0	(39,151)	(39,151)
Balance (in shares) at Dec. 31, 2021																	21,039,594
Balance at Dec. 31, 2021																	$ 2	582,025	(539,805)	$ 42,222
Issuance of common stock upon exercise of options (in shares)																				(0)
Issuance of common stock under employee benefit plans (in shares)																	46,185
Issuance of common stock under employee benefit plans																	$ 0	43	0	$ 43
Issuance of common stock, net (in shares)					54,763				3,185,216				29,308,612
Issuance of common stock, net					$ 0	$ 123	$ 0	$ 123	$ 0	$ 9,291	$ 0	$ 9,291	$ 3	$ 24,144	$ 0	$ 24,147
Stock-based compensation																	0	2,560	0	2,560
Net loss																	$ 0	0	(76,322)	(76,322)
Issuance of common stock upon exercise of pre-funded warrants (in shares)																	6,210,480
Issuance of common stock upon exercise of pre-funded warrants																	$ 1	8,592	0	8,593
Balance (in shares) at Dec. 31, 2022																	59,844,850
Balance at Dec. 31, 2022																	$ 6	$ 626,778	$ (616,127)	$ 10,657