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Note 8 - Common Stock and Common Stock Warrants (Tables)
12 Months Ended
Dec. 31, 2022
Notes Tables  
Reserved Shares of Common Stock for Future Issuances [Table Text Block]
   

December 31,

 
   

2022

   

2021

 

Issuance of equity-based awards under stock plan

    1,001,087       2,131,671  

Issuance upon exercise of options under stock plan

    4,570,432       2,439,253  

Warrants (Pre-funded and March 31, 2022 Warrants)

    20,720,440        

Total

    26,291,959       4,570,924  
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]

Number of Shares

Exercise Price

Expiration Date

3,990,025

$

1.88

March 30, 2027

860,216

$

2.20

March 30, 2027

Security

Number of Shares

Exercise Price

Expiration Date

Pre-Funded

15,870,199

$

0.0001

No expiration

Series A

22,589,410

$

0.7949

April 16, 2024 (1)

Series B

22,589,401

$

0.7949

July 16, 2025