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Note 8 - Stock Based Awards (Tables)
9 Months Ended
Sep. 30, 2021
Notes Tables  
Share-based Payment Arrangement, Option, Activity [Table Text Block]
          

Weighted

     
          

Average

     
      

Weighted

  

Remaining

  

Aggregate

 
      

Average

  

Contractual

  

Intrinsic

 
  

Number of

  

Exercise

  

Life

  

Value

 
  

Shares

  

Price

  

(in years)

  

(in thousands)

 

Balances, January 1, 2021

  2,173,776  $9.59         

Options granted

  865,674   5.55         

Options cancelled

  (457,323)  34.53         

Options exercised

  (148,452)  1.91         

Balances, September 30, 2021

  2,433,675  $3.93   7.0  $3,269 

Outstanding and expected to vest as of September 30, 2021

  2,278,219  $3.77   6.9  $3,269 

Exercisable as of September 30, 2021

  1,473,616  $2.44   5.6  $3,269 
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
  

September 30,

  

September 30,

 
  

2021

  

2020

 

Expected volatility

  114.4%  112.3%

Risk-free interest rate

  0.7%  1.0%

Dividend yield

  0.0%  0.0%

Expected life (in years)

  5.9   6.0