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                          December 13, 2021

       William B. Stilley, III
       President and Chief Executive Officer
       ADIAL PHARMACEUTICALS, INC.
       1180 Seminole Trail, Suite 495
       Charlottesville, VA 22901

                                                        Re: ADIAL
PHARMACEUTICALS, INC.
                                                            Registration
Statement on Form S-3
                                                            Filed on December
6, 2021
                                                            File No. 333-261509

       Dear Mr. Stilley:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jordan
Nimitz at 202-551-5831 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Leslie Marlow, Esq.