The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   1,287,333 430,252 SH   DFND   430,252 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   13,544,624 17,079,778 SH   DFND   17,079,778 0 0
ADDEX THERAPEUTICS LTD SPONSORED ADS 00654J206   305,728 9,000 SH   DFND   9,000 0 0
AFFIMED NV COM N01045108   2,766,555 4,426,488 SH   DFND   4,426,488 0 0
ALLAKOS INC COM 01671P100   16,782,020 6,147,260 SH   DFND   6,147,260 0 0
ARCELLX INC COMMON STOCK 03940C100   207,862,041 3,745,262 SH   DFND   3,745,262 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102   35,688,808 3,969,834 SH   DFND   3,969,834 0 0
BLACK DIAMOND THERAPEUTICS INC COM 09203E105   12,501,007 4,448,757 SH   DFND   4,448,757 0 0
BRIGHT HEALTH GROUP INC COM NEW 10920V404   19,862,942 2,726,917 SH   DFND   2,726,917 0 0
BUZZFEED INC CLASS A COM 12430A102   3,833,473 15,333,892 SH   DFND   15,333,892 0 0
CELCUITY INC COM 15102K100   18,212,525 1,250,001 SH   DFND   1,250,001 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307   9,630,935 1,713,720 SH   DFND   1,713,720 0 0
COURSERA INC COM 22266M104   249,248,686 12,867,769 SH   DFND   12,867,769 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   99,399,660 1,587,854 SH   DFND   1,587,854 0 0
CVRX INC COM 126638105   74,529,841 2,370,542 SH   DFND   2,370,542 0 0
DESKTOP METAL INC COM CL A 25058X105   10,813,594 14,407,594 SH   DFND   14,407,594 0 0
GERON CORP COM 374163103   48,058,223 22,776,409 SH   DFND   22,776,409 0 0
GLYCOMIMETICS INC COM 38000Q102   11,244,079 4,764,440 SH   DFND   4,764,440 0 0
GOSSAMER BIO INC COM 38341P102   14,452,183 15,838,009 SH   DFND   15,838,009 0 0
IKENA ONCOLOGY INC COM 45175G108   1,122,999 570,050 SH   DFND   570,050 0 0
INOZYME PHARMA INC COM 45790W108   10,384,555 2,437,689 SH   DFND   2,437,689 0 0
INVENTIVA SA ADS 46124U107   6,605,038 1,462,586 SH   DFND   1,462,586 0 0
KORRO BIO INC COM 500946108   41,140,658 1,072,936 SH   DFND   1,072,936 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   3,644,898 2,382,286 SH   DFND   2,382,286 0 0
MARKER THERAPEUTICS INC COM NEW 57055L206   5,892,854 1,071,428 SH   DFND   1,071,428 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102   43,461,484 7,692,298 SH   DFND   7,692,298 0 0
MYND AI INC SPON ADS 628988107   1,816,256 23,642,711 SH   DFND   23,642,711 0 0
NEXTNAV INC COMMON STOCK 65345N106   36,441,744 8,189,156 SH   DFND   8,189,156 0 0
NKARTA INC COM 65487U108   23,553,955 3,568,781 SH   DFND   3,568,781 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107   17,896,343 1,960,169 SH   DFND   1,960,169 0 0
REGULUS THERAPEUTICS INC COM 75915K200   2,490,341 1,945,579 SH   DFND   1,945,579 0 0
RENEO PHARMACEUTICALS INC COM 75974E103   7,656,790 4,785,494 SH   DFND   4,785,494 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   133,770,677 2,909,956 SH   DFND   2,909,956 0 0
SAGIMET BIOSCIENCES INC COM SER A 786700104   18,781,641 3,850,275 SH   DFND   3,850,275 0 0
SAVARA INC COM 805111101   115,014,941 24,471,264 SH   DFND   24,471,264 0 0
SENTI BIOSCIENCES INC COM 81726A100   2,921,260 4,426,151 SH   DFND   4,426,151 0 0
SURF AIR MOBILITY INC COM 868927104   307,191 220,209 SH   DFND   220,209 0 0
SYNLOGIC INC COM NEW 87166L209   11,252,673 2,922,774 SH   DFND   2,922,774 0 0
TREVI THERAPEUTICS INC COM 89532M101   15,236,304 11,370,376 SH   DFND   11,370,376 0 0
TUYA INC SPONSERED ADS 90114C107   11,349,672 4,934,640 SH   DFND   4,934,640 0 0
VERONA PHARMA PLC SPONSERED ADS 925050106   111,024,890 5,108,563 SH   DFND   5,108,563 0 0
WHEELS UP EXPERIENCE INC COM CL A 96328L205   364,009 106,126 SH   DFND   106,126 0 0
X4 PHARMACEUTICALS INC COM 98420X103   12,566,426 14,986,793 SH   DFND   14,986,793 0 0
ZEROFOX HLDGS INC COM 98955G103   15,719,606 18,068,513 SH   DFND   18,068,513 0 0