The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACHAOGEN INC COM 004449104 131,578 5,215,128 SH   DFND   5,215,128 0 0
ADAPTIMMUNE THERAPEUTICS PLC ADR 00653A107 66,263 12,025,999 SH   DFND   12,025,999 0 0
AEROHIVE NETWORKS INC COM 007786106 18,144 4,309,691 SH   DFND   4,309,691 0 0
AFFIMED NV COM N01045108 8,944 3,888,888 SH   DFND   3,888,888 0 0
AKARI THERAPEUTICS PLC ADR 00972G108 5,005 452,167 SH   DFND   452,167 0 0
ARCA BIOPHARMA INC COM PAR $.001 00211Y407 3,724 1,460,209 SH   DFND   1,460,209 0 0
ARDELYX INC COM 039697107 178,157 14,083,582 SH   DFND   14,083,582 0 0
ARQULE INC COM 04269E107 2,672 2,520,316 SH   DFND   2,520,316 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 35,294 4,808,483 SH   DFND   4,808,483 0 0
AVEO PHARMACEUTICALS INC COM 053588109 9,654 16,362,694 SH   DFND   16,362,694 0 0
CARE COM INC COM 141633107 40,795 3,260,989 SH   DFND   3,260,989 0 0
CASCADIAN THERAPEUTICS INC COM NEW 14740B606 37,527 9,064,575 SH   DFND   9,064,575 0 0
CATALYST BIOSCIENCES INC COM NEW 14888D208 410 43,492 SH   DFND   43,492 0 0
CERECOR INC COM 15671L109 402 595,435 SH   DFND   595,435 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307 4,953 1,562,500 SH   DFND   1,562,500 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 70,115 3,220,728 SH   DFND   3,220,728 0 0
DASAN ZHONE SOLUTIONS INC COM NEW 23305L206 5,972 956,255 SH   DFND   956,255 0 0
DERMIRA INC COM 24983L104 119,612 3,506,649 SH   DFND   3,506,649 0 0
ENDOLOGIX INC COM 29266S106 18,029 2,490,204 SH   DFND   2,490,204 0 0
EPIZYME INC COM 29428V104 107,374 6,260,851 SH   DFND   6,260,851 0 0
GLYCOMIMETICS INC COM 38000Q102 46,612 8,584,128 SH   DFND   8,584,128 0 0
GROUPON INC COM 399473107 59,173 15,056,822 SH   DFND   15,056,822 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302 34,162 2,382,286 SH   DFND   2,382,286 0 0
MIRNA THERAPEUTICS INC COM 60470J103 6,515 2,974,811 SH   DFND   2,974,811 0 0
NEVRO CORP COM 64157F103 33,702 359,678 SH   DFND   359,678 0 0
OBSEVA SA COM H5861P103 34,734 3,336,563 SH   DFND   3,336,563 0 0
OREXIGEN THERAPEUTICS INC COM NEW 686164302 1,276 370,900 SH   DFND   370,900 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 1,275 66,245 SH   DFND   66,245 0 0
PROTEOSTASIS THERAPEUTICS INC COM 74373B109 27,814 3,556,778 SH   DFND   3,556,778 0 0
RA PHARMACEUTICALS INC COM 74933V108 74,380 3,493,636 SH   DFND   3,493,636 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 10,375 3,243,150 SH   DFND   3,243,150 0 0
ROKA BIOSCIENCE INC COM NEW 775431208 3,181 893,471 SH   DFND   893,471 0 0
SENSEONICS HOLDINGS INC COM 81727U105 47,086 26,305,286 SH   DFND   26,305,286 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 19,671 4,141,308 SH   DFND   4,141,308 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 5,323 1,298,274 SH   DFND   1,298,274 0 0
TESARO INC COM 881569107 1,581,032 10,275,113 SH   DFND   10,275,113 0 0
TRACON PHARMACEUTICALS INC COM 89237H100 10,347 2,759,217 SH   DFND   2,759,217 0 0
TREVENA INC COM 89532E109 13,989 3,811,691 SH   DFND   3,811,691 0 0