The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   3,364,716 17,079,778 SH   DFND   17,079,778 0 0
AFFIMED N V ORDINARY SHS NEW N01045207   320,123 442,648 SH   DFND   442,648 0 0
ALLAKOS INC COM 01671P100   1,399,116 6,147,260 SH   DFND   6,147,260 0 0
ARCELLX INC COMMON STOCK 03940C100   245,689,187 3,745,262 SH   DFND   3,745,262 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102   31,917,465 3,969,834 SH   DFND   3,969,834 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   6,895,573 4,448,757 SH   DFND   4,448,757 0 0
BUZZFEED INC CL A NEW 12430A300   5,350,779 2,512,103 SH   DFND   3,833,473 0 0
CELCUITY INC COM 15102K100   12,637,510 1,250,001 SH   DFND   1,250,001 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307   14,875,090 1,713,720 SH   DFND   1,713,720 0 0
COURSERA INC COM 22266M104   85,699,342 12,867,769 SH   DFND   12,867,769 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   54,034,672 1,587,854 SH   DFND   1,587,854 0 0
CVRX INC COM 126638105   24,778,995 2,026,083 SH   DFND   2,026,083 0 0
DESKTOP METAL INC COM CL A 25058X303   7,069,869 1,439,892 SH   DFND   1,439,892 0 0
GOSSAMER BIO INC COM 38341P102   19,902,337 18,093,034 SH   DFND   18,093,034 0 0
IKENA ONCOLOGY INC COM 45175G108   768,081 600,063 SH   DFND   600,063 0 0
INOZYME PHARMA INC COM 45790W108   2,218,297 2,437,689 SH   DFND   2,437,689 0 0
INVENTIVA SA ADS 46124U107   4,300,003 1,462,586 SH   DFND   1,462,586 0 0
KORRO BIO INC COM 500946108   18,990,706 1,090,793 SH   DFND   1,090,793 0 0
MARKER THERAPEUTICS INC COM NEW 57055L206   1,999,584 1,625,678 SH   DFND   1,625,678 0 0
MBX BIOSCIENCES INC COM 55287L101   26,674,907 3,614,486 SH   DFND   3,614,486 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102   35,692,263 7,692,298 SH   DFND   7,692,298 0 0
NEUEHEALTH INC COM NEW 10920V404   18,433,959 2,726,917 SH   DFND   2,726,917 0 0
NKARTA INC COM 65487U108   6,566,557 3,568,781 SH   DFND   3,568,781 0 0
ONKURE THERAPEUTICS INC COM CL A 68277Q105   2,057,756 478,548 SH   DFND   478,548 0 0
ORIC PHARMACEUTICALS INC COM 68622P109   12,251,141 2,195,545 SH   DFND   1,566,081 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107   12,290,260 1,960,169 SH   DFND   1,960,169 0 0
REGULUS THERAPEUTICS INC COM 75915K309   11,318,654 6,467,802 SH   DFND   6,467,802 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   154,140,369 2,909,956 SH   DFND   2,909,956 0 0
SAVARA INC COM 805111101   67,785,401 24,471,264 SH   DFND   24,471,264 0 0
SENTI BIOSCIENCES INC COM NEW 81726A209   12,686,066 3,775,615 SH   DFND   442,615 0 0
SYNLOGIC INC COM NEW 87166L209   3,624,237 2,922,772 SH   DFND   2,922,772 0 0
TEMPUS AI INC CL A 88023B103   126,194,827 2,615,979 SH   DFND   5,385,979 0 0
TREVI THERAPEUTICS INC COM 89532M101   71,519,665 11,370,376 SH   DFND   11,370,376 0 0
TUYA INC SPONSERED ADS 90114C107   0 0 SH   DFND   0 0 0
VERONA PHARMA PLC SPONSERED ADS 925050106   170,696,992 2,688,565 SH   DFND   5,584,753 0 0
WHEELS UP EXPERIENCE INC COM CL A 96328L205   107,186 106,125 SH   DFND   106,125 0 0
X4 PHARMACEUTICALS INC COM 98420X103   3,542,878 14,986,793 SH   DFND   14,986,793 0 0
ZENAS BIOPHARMA INC COM 98937L105   20,650,189 2,613,948 SH   DFND   2,613,948 0 0