X0306 4 2020-02-06 0 0001427925 ACELRX PHARMACEUTICALS INC ACRX 0001511368 Hamel Lawrence G C/O ACELRX PHARMACEUTICALS, INC. 351 GALVESTON DRIVE REDWOOD CITY CA 94063 0 1 0 0 Chief Development Officer Common Stock 2020-02-06 4 A 0 50000 0.00 A 133382 D Common Stock 29795 I By the Hamel Revocable Living Trust Stock Option (Right to Buy) 1.72 2020-02-06 4 A 0 100000 0.00 A 2030-02-06 Common Stock 100000 100000 D Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units shall vest in three equal consecutive annual installments on February 6, 2021, February 6, 2022 and February 6, 2023. The shares subject to the option vest as follows: 25% of the shares subject to the option vest on the 12 month anniversary of the grant date and the remaining shares subject to the option vest on an equal monthly basis over the following 36 months. /s/ Ruben Garcia, Attorney-In-Fact 2020-02-07