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Income Taxes - Reconciliation of statutory income tax rate to effective income tax rate (Details)
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Reconciliation of the statutory income tax rate to the Company's effective income tax rate    
Income at US Statutory Rate 21.00% 21.00%
State taxes, net of federal benefit 6.00% 7.20%
Permanent differences 0.70% 0.60%
Research and development credits 1.00% 1.50%
Foreign rate differential 0.30% 0.20%
Change in valuation allowance (27.30%) (30.60%)
Other 2.00% 0.10%
Effective income tax rate 0.30% 0.00%