X0306 4 2022-09-01 0 0001509745 LEAP THERAPEUTICS, INC. LPTX 0001808556 O'Mahony John Mark C/O LEAP THERAPEUTICS, INC. 47 THORNDIKE STREET SUITE B1-1 CAMBRIDGE MA 02141 0 1 0 0 Chief Manufacturing Officer Employee Stock Option (Right to Buy) 1.43 2022-09-01 4 A 0 200000 0 A 2032-08-31 Common Stock 200000 200000 D The Option was granted pursuant to Leap's 2022 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one month anniversary of September 1, 2022, the Vesting Start Date. /s/ Douglas E. Onsi, as attorney-in-fact for John Mark O'Mahony 2022-09-02