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Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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Amount of cost to be recognized for nonvested award under share-based payment arrangement. Excludes share and unit options.

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The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

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The weighted average fair value at grant date for nonvested equity-based awards issued during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

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The number of non-vested equity-based payment instruments, excluding stock (or unit) options, that validly exist and are outstanding as of the balance sheet date.

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Per share or unit weighted-average fair value of nonvested award under share-based payment arrangement. Excludes share and unit options.

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Fair value of share-based awards for which the grantee gained the right by satisfying service and performance requirements, to receive or retain shares or units, other instruments, or cash.

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The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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The risk-free interest rate assumption that is used in valuing an option on its own shares.

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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Gross number of share options (or share units) granted during the period.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Amount by which current fair value of underlying stock exceeds exercise price of fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Number of fully vested and expected to vest options outstanding that can be converted into shares under option plan. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted-average exercise price, at which grantee can acquire shares reserved for issuance, for fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options that were terminated.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Expected term of award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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Equity Incentive Plans (Details) - USD ($) $ / shares in Units, $ in Thousands		3 Months Ended		12 Months Ended
	Jan. 20, 2017	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Options
Outstanding balance at the beginning of the period (in shares)		8,525,618
Granted (in shares)		650,000
Forfeited (in shares)		(74,111)
Outstanding balance at the end of the period (in shares)		9,101,507		8,525,618
Options exercisable at the end of the period (in shares)		5,983,001
Options vested and expected to vest at end of period (in shares)		9,101,507
Weighted Average Exercise Price Per Share
Outstanding balance at the beginning of the period (in dollars per share)		$ 4.48
Granted (in dollars per share)		1.97
Forfeited (in dollars per share)		2.11
Outstanding balance at the end of the period (in dollars per share)		4.32		$ 4.48
Exercisable at the end of the period (in dollars per share)		5.48
Options vested and expected to vest at end of the period (in dollars per share)		$ 4.32
Weighted Average Remaining Life in Years
Outstanding balance		7 years 5 months 12 days		7 years 6 months 29 days
Options exercisable at end of period		6 years 8 months 23 days
Options vested and expected to vest at end of the period		7 years 5 months 12 days
Aggregate Intrinsic Value
Outstanding balance		$ 697		$ 7,673
Options exercisable at the end of the period		514
Options vested and expected to vest at end of the period		$ 697
Assumptions used to determine grant-date fair value
Expected Volatility		82.70%	66.94%
Weighted average risk-free interest rate		1.67%	0.66%
Expected dividend yield		0.00%	0.00%
Expected term (in years)		6 years 3 days	6 years 10 months 9 days
Expiration period		10 years
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value		$ 1.39	$ 1.57
Compensation cost related to the non-vested awards not yet recognized		$ 3,901
Weighted average period for recognition of compensation cost		1 year 9 months 25 days
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Outstanding at end(in dollars per share)		$ 1.39	$ 1.57
Minimum
Assumptions used to determine grant-date fair value
Vesting period		3 years
Maximum
Assumptions used to determine grant-date fair value
Vesting period		4 years
2016 Plan
Assumptions used to determine grant-date fair value
Annual increase in authorized shares (as a percent)	4.00%
Number of options or stock awards available for grant under the Plan		791,745
Options to purchase common stock
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Stock-based compensation expense		$ 1,204	$ 833
Options to purchase common stock \| Research and development
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Stock-based compensation expense		554	345
Options to purchase common stock \| General and administrative
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Stock-based compensation expense		650	$ 488
Restricted stock units to purchase common stock
Assumptions used to determine grant-date fair value
Aggregate grant fair value		6,640
Share-based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount		$ 5,452
Weighted average period for recognition of compensation cost		2 years 7 months 28 days
Restricted stock units to purchase common stock \| Executive Officer [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Awarded		2,575,000	275,000
Restricted stock units to purchase common stock \| 2016 Plan
Assumptions used to determine grant-date fair value
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value		$ 1.89		$ 1.76
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Outstanding at the beginning		935,606	753,106	753,106
Awarded		2,575,000		275,000
Settled in cash				(92,500)
Outstanding at the end		3,510,606		935,606
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Outstanding at beginning( in dollars per share)		$ 1.76	$ 1.52	$ 1.52
Awarded (in dollars per share)		1.94		2.57
Settled in cash(in dollars per share)				1.97
Outstanding at end(in dollars per share)		$ 1.89		$ 1.76