X0306 4 2020-08-10 0 0001509745 LEAP THERAPEUTICS, INC. LPTX 0001262327 LAWLOR AUGUSTINE C/O LEAP THERAPEUTICS, INC. 47 THORNDIKE STREET SUITE B1-1 CAMBRIDGE MA 02141 0 1 1 0 Chief Operating Officer Stock Option (Right to Buy) 1.97 2020-08-10 4 A 0 75000 0 A 2030-08-09 Common Stock 75000 75000 D The Option was granted pursuant to Leap's 2016 Equity Incentive Plan and shall vest and become exercisable in a series of 36 equal monthly installments until the Option is fully vested, with the first such monthly installment vesting on the one month anniversary of August 10, 2020, the Vesting Start Date. /s/ Douglas E. Onsi as attorney-in-fact for Augustine Lawlor 2020-08-12