X0306 4 2018-07-30 0 0001509745 LEAP THERAPEUTICS, INC. LPTX 0001013603 WERNER HAROLD R C/O LEAP THERAPEUTICS, INC. 47 THORNDIKE STREET SUITE B1-1 CAMBRIDGE MA 02141 0 0 1 0 Warrant (Right to Buy) 6.085 2018-07-30 4 J 0 2137 0 A 2017-11-14 2024-11-14 Common Stock 2137 2137 I See Footnote Pro rata distribution from HealthCare Ventures IX, L.P. to its limited partner, Werner Family Investment L.P. Harold R. Werner is the general partner of Werner Family Investment L.P. The reporting person is also a Managing Director of HealthCare Partners VIII, LLC, which is General Partner of HealthCare Partners VIII, L.P., which is the General Partner of HealthCare Ventures VIII, L.P. ("HCV VIII"). HCV VIII continues to hold 2,618,406 shares of common stock, representing 17.8% of the outstanding shares of common stock. /s/ Jeffrey B. Steinberg as attorney-in-fact for Harold R. Werner 2018-08-01