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Income Taxes - Reconciliation of Statutory and Effective Tax Rates (Details)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Reconciliation of the statutory tax rate to the Company's effective tax rate    
Federal statutory income tax rate 21.00% 34.00%
State taxes, net of federal benefit 7.76% 4.42%
Permanent differences 2.38% (2.27%)
Tax credits 6.94% 3.45%
Tax law change 0.00% (37.65%)
Foreign rate differential 0.68% (0.02%)
Valuation allowance (38.26%) (3.11%)
Other (0.59%) 1.68%
Effective income tax rate (0.09%) 0.50%