X0306 4 2015-06-15 0 0001373707 TETRAPHASE PHARMACEUTICALS INC TTPH 0001509643 THOMPSON JOHN CRAIG 480 ARSENAL ST SUITE 110 WATERTOWN MA 02472 0 1 0 0 Chief Operating Officer Common Stock 2015-06-15 4 M 0 10000 14.45 A 10343 D Common Stock 2015-06-15 4 S 0 10000 41.51 D 343 D Employee Stock Option (right to buy) 14.45 2015-06-15 4 M 0 10000 0.00 D 2024-02-02 Common Stock 10000 187501 D The exercise and sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 13, 2015. The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $40.77 to $42.23 per share. The reporting person herby undertakes, upon request of the staff of the U.S. Securities and Exchange Commission, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. This option vested as to 20% of the shares on February 3, 2014 and another 20% on February 3, 2015 and further vests as to 5% of the shares at the end of each successive three-month period thereafter until February 3, 2018. /s/Maria Stahl as Attorney-in-Fact for John Craig Thompson 2015-06-16