President

0001493152-25-028552.txt : 20251219 0001493152-25-028552.hdr.sgml : 20251219 20251219160516 ACCESSION NUMBER: 0001493152-25-028552 CONFORMED SUBMISSION TYPE: SCHEDULE 13G PUBLIC DOCUMENT COUNT: 2 FILED AS OF DATE: 20251219 DATE AS OF CHANGE: 20251219 SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: Rezolute, Inc. CENTRAL INDEX KEY: 0001509261 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] ORGANIZATION NAME: 03 Life Sciences EIN: 273440894 STATE OF INCORPORATION: NV FISCAL YEAR END: 0630 FILING VALUES: FORM TYPE: SCHEDULE 13G SEC ACT: 1934 Act SEC FILE NUMBER: 005-86686 FILM NUMBER: 251587499 BUSINESS ADDRESS: STREET 1: 275 SHORELINE DRIVE, SUITE 500 CITY: REDWOOD CITY STATE: CA ZIP: 94065 BUSINESS PHONE: 650-206-4507 MAIL ADDRESS: STREET 1: 275 SHORELINE DRIVE, SUITE 500 CITY: REDWOOD CITY STATE: CA ZIP: 94065 FORMER COMPANY: FORMER CONFORMED NAME: AntriaBio, Inc. DATE OF NAME CHANGE: 20130114 FORMER COMPANY: FORMER CONFORMED NAME: FITS MY STYLE INC DATE OF NAME CHANGE: 20110104 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: Opaleye Management Inc. CENTRAL INDEX KEY: 0001595855 ORGANIZATION NAME: EIN: 205648796 STATE OF INCORPORATION: MA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SCHEDULE 13G BUSINESS ADDRESS: STREET 1: ONE BOSTON PLACE STREET 2: SUITE 2600 CITY: BOSTON STATE: MA ZIP: 02108 BUSINESS PHONE: 617-904-9195 MAIL ADDRESS: STREET 1: ONE BOSTON PLACE STREET 2: SUITE 2600 CITY: BOSTON STATE: MA ZIP: 02108 SCHEDULE 13G 1 primary_doc.xml SCHEDULE 13G 0001595855 XXXXXXXX LIVE Common Stock 12/12/2025 0001509261 Rezolute, Inc. 76200L309 275 SHORELINE DRIVE, SUITE 500 REDWOOD CITY CA 94065 Rule 13d-1(b) Opaleye Management Inc. MA 0.00 4912900.00 0.00 4912900.00 4912900.00 N 5.30 IA CO Opaleye, L.P. MA 0.00 4785000.00 0.00 4785000.00 4785000.00 N 5.16 PN Based on 92,727,532 Common Shares outstanding as of 11/04/2025 as reported by Rezolute, Inc. on 11/06/2025, in its 10Q Quarterly Report. James Silverman X1 0.00 4912900.00 0.00 4912900.00 4912900.00 N 5.30 IN Rezolute, Inc. 275 SHORELINE DRIVE, SUITE 500 REDWOOD CITY CA 94065 Opaleye Management Inc. Opaleye, L.P. James Silverman This statement is filed by (i) Opaleye Management Inc. (the "Adviser"), (ii) Opaleye, L.P. (the "Fund") and (iii) James Silverman with respect to shares directly held by the Fund. The Adviser serves as investment adviser to the Fund. Mr. Silverman exercises control over the Adviser. The filing of this statement should not be construed as an admission that any of the foregoing persons is, for the purposes of Section 13 of the Securities Exchange Act, the beneficial owner of the shares reported herein. One Boston Place, 26th Floor, Boston, MA 02108 Opaleye Management Inc. - Massachusetts Opaleye, L.P. - Massachusetts James Silverman - USA N IA HC 4,912,900.00 5.30 0 4,912,900.00 0 4,912,900.00 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99.1 Joint Filing Agreement by and among the reporting persons Opaleye Management Inc. /s/ James Silverman President 12/19/2025 Opaleye, L.P. /s/ James Silverman General Partner 12/19/2025 James Silverman /s/ James Silverman Individually 12/19/2025 EX-99.1 2 ex99-1.htm EX-99.1

Exhibit 99.1

JOINT FILING AGREEMENT

This Joint Filing Agreement, dated as of August 29, 2025, is by and among Opaleye Management Inc., Opaleye, L.P. and James Silverman (collectively, the “Filers”).

Each of the Filers may be required to file with the United States Securities and Exchange Commission a statement on Schedule 13D and/or 13G with respect to Ordinary Shares of Rezolute, Inc. beneficially owned by them from time to time.

Pursuant to and in accordance with Rule 13(d)(1)(k) promulgated under the Securities Exchange Act of 1934, as amended, the Filers hereby agree to file a single statement on Schedule 13D and/or 13G (and any amendments thereto) on behalf of each of the Filers, and hereby further agree to file this Joint Filing Agreement as an exhibit to such statement, as required by such rule.

This Joint Filing Agreement may be terminated by any of the Filers upon written notice or such lesser period of notice as the Filers may mutually agree.

Executed and delivered as of the date first above written.

	OPALEYE MANAGEMENT INC.

	By:	/s/ James Silverman
	Name:	James Silverman
	Title:	President

	OPALEYE, L.P.

	By:	/s/ James Silverman
	Name:	James Silverman
	Title:	General Partner

	JAMES SILVERMAN

	/s/ James Silverman