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                          November 19, 2020

       Nevan Elam
       Chief Executive Officer
       Rezolute, Inc.
       201 Redwood Shores Parkway, Suite 315
       Redwood City, CA 94065

                                                        Re: Rezolute, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed November 13,
2020
                                                            File No. 333-250073

       Dear Mr. Elam:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Chris
Edwards at 202-551-6761 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Anthony W. Epps