Consolidated Statements Of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015
Cash flows from operating activities
Net loss	$ (10,242)	$ (71,199)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Stock-based compensation expense	6,536	6,489
Depreciation and amortization expense	738	1,596
Impairment of intangible assets	2,780	43,398
Gain on sale of marketable securities		(3,874)
Non-cash interest expense	358	30
Market value adjustments to inventories	1,552
Change in fair value of contingent consideration		(1,248)
Change in fair value of derivative instruments		(1,274)
Loss on disposition of property and equipment	5
Deferred tax benefit		(1,389)
Changes in operating assets and liabilities:
Accounts receivable, net	45	208
Inventories	(5,821)	(746)
Prepaid expenses and other current assets	(941)	(236)
Other assets	13	(114)
Accounts payable	3,712	(274)
Accrued expenses and other liabilities	(487)	529
Licensing and collaboration commitment	7,000
Net cash provided by (used in) operating activities	5,248	(28,104)
Cash flows from investing activities
Milestone payments for intangible assets	(1,000)
Purchases of property and equipment, net	(25)	(1,856)
Proceeds from sales of marketable securities		7,456
Purchase of investments	(228,840)	(1,592,747)
Proceeds from maturities of investments	286,793	1,621,749
Net cash provided by investing activities	56,928	34,602
Cash flows from financing activities
Proceeds from stock options exercised	54	311
Proceeds from issuance of common stock under sales agreement, net of commission	12,072
Payments for sales agreement costs	(262)
Cash paid for contingent consideration		(3,000)
Net cash provided by (used in) financing activities	11,864	(2,689)
Effect of exchange rate on cash	52	(111)
Net increase in cash and cash equivalents	74,092	3,698
Cash and cash equivalents, beginning of period	26,755	9,823
Cash and cash equivalents, end of period	100,847	13,521
Supplemental disclosure of cash flow information
Cash paid for interest	2,179	628
Supplemental disclosure of noncash investing and financing activities:
Non-cash exercise of warrants		$ 750
Receivable from broker for issuance of common stock	$ 605