Consolidated Statements Of Operations - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Revenues
Licensing and collaboration revenue			$ 38,151
Product sales	$ 40	$ 229	108	$ 615
Total revenues	40	229	38,259	615
Costs and expenses
Cost of product sales	286	138	2,046	357
Royalty expense	19	23	57	66
Research and development	5,334	6,197	21,386	18,499
Selling, general and administrative	6,924	4,997	19,623	14,061
Amortization of intangible assets	91	483	281	1,449
Impairment of intangible assets		43,398	2,780	43,398
Total costs and expenses	12,654	55,236	46,173	77,830
Loss from operations	(12,614)	(55,007)	(7,914)	(77,215)
Other income (expense)
Interest income	116	33	276	147
Interest expense	(859)	(226)	(2,554)	(661)
Other income (expense), net	(14)		(50)	5,141
Total other income (expense)	(757)	(193)	(2,328)	4,627
Loss before income taxes	(13,371)	(55,200)	(10,242)	(72,588)
Income tax benefit	0	758	0	1,389
Net loss	$ (13,371)	$ (54,442)	$ (10,242)	$ (71,199)
Net loss per share, basic and diluted	$ (0.38)	$ (1.58)	$ (0.29)	$ (2.08)
Weighted average shares outstanding, basic and diluted	35,092,686	34,405,646	34,837,169	34,293,357