<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2020-03-02</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001178670</issuerCik>
        <issuerName>ALNYLAM PHARMACEUTICALS, INC.</issuerName>
        <issuerTradingSymbol>ALNY</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001508518</rptOwnerCik>
            <rptOwnerName>BRANDICOURT OLIVIER</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>675 WEST KENDALL STREET</rptOwnerStreet1>
            <rptOwnerStreet2>HENRI A. TERMEER SQUARE</rptOwnerStreet2>
            <rptOwnerCity>CAMBRIDGE</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02142</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <ownerSignature>
        <signatureName>By: /s/ Mary Beth DeLena, Attorney-in-Fact For: Olivier Brandicourt</signatureName>
        <signatureDate>2020-03-02</signatureDate>
    </ownerSignature>
</ownershipDocument>
