X0206 3 2019-11-06 0 0001571498 Epizyme, Inc. EPZM 0001507678 Legorreta Pablo G. C/O RP MANAGEMENT, LLC 110 E. 59TH ST., 33RD FLOOR NEW YORK NY 10022 1 0 0 0 0001507673 RP Management, LLC C/O RP MANAGEMENT, LLC 110 E. 59TH ST., 33RD FLOOR NEW YORK NY 10022 1 0 0 0 0001793690 RPI Finance Trust C/O RP MANAGEMENT, LLC 110 E. 59TH ST., 33RD FLOOR NEW YORK NY 10022 1 0 0 0 Common Stock 6666667 I See footnotes Warrant (Right to Buy) 20.00 2019-11-06 2022-11-06 Common Stock 2500000 I See footnotes Represents 6,666,667 shares of the Issuer's common stock acquired by RPI Finance Trust ("RPIFT") on November 6, 2019 pursuant to that certain Purchase Agreement, dated November 4, 2019, by and between the Issuer and RPIFT (the "Purchase Agreement"). This Form 3 is being jointly filed by RP Management, LLC ("RP Management"), RPIFT and Pablo G. Legorreta (collectively, the "Reporting Persons"). RP Management, as the manager of RPIFT, and Mr. Legorreta, as the manager of RP Management, may be deemed to have beneficial ownership under Section 13 of the Securities Exchange Act of 1934, as amended (the "Exchange Act") of the securities beneficially owned by RPIFT. RP Management and Mr. Legorreta disclaim beneficial ownership of the securities indicated except to the extent of their pecuniary interest therein, and the reporting herein of such securities shall not be construed as an admission that RP Management and/or Mr. Legorreta are the beneficial owners thereof for purposes of Section 16 of the Exchange Act or for any other purpose. (Continued from Footnote 2) Mr. Legorreta serves on the board of directors of the Issuer as a representative of RPIFT. Each of RPIFT and RP Management, LLC may be deemed to be a director by deputization of the Issuer for purposes of Section 16(b)-3(d) of the Exchange Act. Pursuant to the terms of the Purchase Agreement, on November 6, 2019, RPIFT acquired a warrant to purchase up to 2,500,000 shares of the Issuer's common stock at a price of $20.00 per share, subject to adjustment in accordance with the terms thereof (the "Warrant"). The Warrant is immediately exercisable, in whole or in part, and terminates on November 6, 2022. /s/ Pablo G. Legorreta 2019-11-08 RP Management, LLC, By: /s/ Pablo G. Legorreta, Chief Executive Officer 2019-11-08 RPI Finance Trust, By: RP Management, LLC, its Administrator, /s/ Pablo G. Legorreta, Chief Executive Officer 2019-11-08