Stockholders' Equity (Details) $ / shares in Units, $ in Millions																	12 Months Ended
	Oct. 17, 2023 USD ($) $ / shares shares	Oct. 17, 2023 AUD ($)	Oct. 12, 2023 shares $ / shares	Jun. 19, 2023 Tranche $ / shares shares	Dec. 08, 2022	Dec. 05, 2022	Oct. 18, 2022 USD ($) $ / shares shares	Sep. 17, 2021 USD ($) $ / shares shares	Mar. 19, 2021 USD ($) $ / shares shares	Aug. 21, 2020 USD ($) $ / shares shares	May 05, 2020 USD ($) $ / shares shares	Apr. 01, 2020 USD ($) shares	Mar. 23, 2020 USD ($) $ / shares shares	Jan. 28, 2020 USD ($) $ / shares shares	Mar. 12, 2019 $ / shares	Nov. 27, 2017 USD ($) $ / shares shares	Dec. 31, 2023 USD ($) $ / shares shares	Dec. 31, 2022 $ / shares shares	Sep. 30, 2022 $ / shares	Apr. 02, 2020 $ / shares shares	Nov. 06, 2019 $ / shares	Oct. 25, 2019 $ / shares	May 30, 2019 $ / shares shares	Jul. 03, 2018 $ / shares
Class of Stock Disclosures [Abstract]
Preferred stock, shares outstanding (in shares)																	0	0
Reverse stock split					0.01
Preferred stock, par value (in dollars per share) | $ / shares																	$ 0.0001	$ 0.0001
Common stock, par value (in dollars per share) | $ / shares																	$ 0.0001	$ 0.0001
Minimum [Member]
Class of Stock Disclosures [Abstract]
Reverse stock split						0.02
Period of warrants expected to vest																	1 year
Maximum [Member]
Class of Stock Disclosures [Abstract]
Reverse stock split						0.01
Period of warrants expected to vest																	4 years
Maximum [Member] | Supply Agreement [Member]
Class of Stock Disclosures [Abstract]
Period for ultrafiltration services				10 years
January 2020 Offering [Member]
Class of Stock Disclosures [Abstract]
Warrants to purchase shares of common stock (in shares)														5,855
Exercise price of warrants (in dollars per share) | $ / shares							$ 25						$ 900	$ 1,650					$ 250
Issuance of common stock, net (in shares)														2,015
Public offering price (in dollars per share) | $ / shares														$ 1,650
Gross proceeds from public stock offering | $														$ 9,700,000
Net proceeds from public stock offering | $														8,600,000
Down-round protection in connection with re-pricing of warrants | $														200,000
Beneficial conversion amount | $														$ 1,600,000
March 2020 Offering [Member]
Class of Stock Disclosures [Abstract]
Warrants to purchase shares of common stock (in shares)													1,387
Exercise price of warrants (in dollars per share) | $ / shares													$ 1,118
Issuance of common stock, net (in shares)													1,387
Public offering price (in dollars per share) | $ / shares													$ 900
Gross proceeds from public stock offering | $													$ 1,200,000
Net proceeds from public stock offering | $													$ 1,000,000
Warrant expiry period																	5 years 6 months
Warrants exercisable period																	6 months
April 2020 Offering [Member]
Class of Stock Disclosures [Abstract]
Warrants to purchase shares of common stock (in shares)																				855
Exercise price of warrants (in dollars per share) | $ / shares																				$ 1,115
Issuance of common stock, net (in shares)												1,710
Public offering price (in dollars per share) | $ / shares																				$ 1,302
Gross proceeds from public stock offering | $												$ 2,200,000
Warrant expiry period																	5 years 6 months
May 2020 Offering [Member]
Class of Stock Disclosures [Abstract]
Warrants to purchase shares of common stock (in shares)											600
Exercise price of warrants (in dollars per share) | $ / shares											$ 1,230
Issuance of common stock, net (in shares)											1,199
Public offering price (in dollars per share) | $ / shares											$ 1,418
Gross proceeds from public stock offering | $											$ 1,700,000
Warrant expiry period																	5 years 6 months
August 2020 Offering [Member]
Class of Stock Disclosures [Abstract]
Issuance of common stock, net (in shares)										10,647
Public offering price (in dollars per share) | $ / shares										$ 1,350
Gross proceeds from public stock offering | $										$ 14,400,000
Net proceeds from public stock offering | $										$ 13,000,000
Number of shares issuable on the exercise of warrants (in shares)										10,647
Warrant expiry period																	5 years
March 2021 Offering [Member]
Class of Stock Disclosures [Abstract]
Issuance of common stock, net (in shares)									37,958
Gross proceeds from public stock offering | $									$ 20,900,000
Net proceeds from public stock offering | $									$ 18,900,000
September 2021 Offering [Member]
Class of Stock Disclosures [Abstract]
Issuance of common stock, net (in shares)								40,056
Gross proceeds from public stock offering | $								$ 10,000,000
Net proceeds from public stock offering | $								$ 9,000,000
October 2022 Offering [Member]
Class of Stock Disclosures [Abstract]
Gross proceeds from public stock offering | $							$ 11,000,000
Net proceeds from public stock offering | $							9,400,000
Financing expense | $							$ 7,700,000
At-the-Market Program [Member]
Class of Stock Disclosures [Abstract]
Issuance of common stock, net (in shares)																	657,333
Gross proceeds from public stock offering | $																	$ 2,300,000
Net proceeds from public stock offering | $																	$ 2,100,000
Aggregate cash fee paid to underwriter or placement agent																	3.00%
Warrants to Purchase Common Stock [Member]
Class of Stock Disclosures [Abstract]
Number of warrants vested (in shares)																	0
Warrants to Purchase Common Stock [Member] | Consultant [Member]
Class of Stock Disclosures [Abstract]
Warrants to purchase shares of common stock (in shares)																							33
Exercise price of warrants (in dollars per share) | $ / shares																							$ 9,540
DaVita Warrant [Member] | Supply Agreement [Member]
Class of Stock Disclosures [Abstract]
Warrants to purchase shares of common stock (in shares)				1,289,081
Exercise price of warrants (in dollars per share) | $ / shares				$ 3.2996
Number of warrants vested (in shares)																	0
Common stock, par value (in dollars per share) | $ / shares				$ 0.0001
Number of tranches | Tranche				4
DaVita Warrant [Member] | Supply Agreement [Member] | Tranche One [Member]
Class of Stock Disclosures [Abstract]
Percentage of warrants expected to vest				25.00%
DaVita Warrant [Member] | Supply Agreement [Member] | Tranche Two [Member]
Class of Stock Disclosures [Abstract]
Percentage of warrants expected to vest				25.00%
Period of warrants expected to vest				12 months
DaVita Warrant [Member] | Supply Agreement [Member] | Tranche Three [Member]
Class of Stock Disclosures [Abstract]
Percentage of warrants expected to vest				25.00%
Period of warrants expected to vest				24 months
DaVita Warrant [Member] | Supply Agreement [Member] | Tranche Four [Member]
Class of Stock Disclosures [Abstract]
Percentage of warrants expected to vest				25.00%
Period of warrants expected to vest				36 months
DaVita Warrant [Member] | Maximum [Member] | Supply Agreement [Member]
Class of Stock Disclosures [Abstract]
Warrants to be exercised for amount of shares ownership percentage in entity				19.90%
Common Stock [Member]
Class of Stock Disclosures [Abstract]
Issuance of common stock, net (in shares)																	657,333	209,940
Common Stock [Member] | October 2022 Offering [Member]
Class of Stock Disclosures [Abstract]
Issuance of common stock, net (in shares)							209,940
Warrants [Member]
Class of Stock Disclosures [Abstract]
Warrants outstanding (in shares)																	6,532	6,532
Warrants [Member] | October 2023 Offering [Member]
Class of Stock Disclosures [Abstract]
Financing expense | $		$ 2.7
Gross proceeds before deducting placement agent fees and commissions and offering expenses | $	$ 2,250,000
Net proceeds after deducting placement agent fees and commissions and offering expenses | $	$ 1,500,000
Series F Convertible Preferred Stock [Member]
Class of Stock Disclosures [Abstract]
Gross proceeds from issuance of convertible preferred stock | $																$ 18,000,000
Net proceeds from issuance of convertible preferred stock | $																$ 16,200,000
Conversion price (in dollars per share) | $ / shares																$ 189,000								$ 89,040
Number of consecutive trading days considered for expiration																	20 days
Number of consecutive trading days																	30 days
Preferred stock issued (in shares)																18,000	127	127
Number of shares issuable on conversion of preferred stock (in shares)																96
Preferred stock, shares outstanding (in shares)																	127	127
Preferred stock, par value (in dollars per share) | $ / shares																	$ 0.0001	$ 0.0001
Aggregate cash fee paid to underwriter or placement agent															8.00%
Series F Convertible Preferred Stock [Member] | Minimum [Member]
Class of Stock Disclosures [Abstract]
Percentage of volume weighted average price of common stock																300.00%
Trading volume for each trading day | $																$ 200,000
Series F Convertible Preferred Stock [Member] | March 2019 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share) | $ / shares															$ 15,750
Series F Convertible Preferred Stock [Member] | October 2019 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share) | $ / shares																						$ 4,230
Series F Convertible Preferred Stock [Member] | November 2019 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share) | $ / shares																					$ 2,983
Series F Convertible Preferred Stock [Member] | January 2020 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share) | $ / shares														$ 1,650
Exercise price of warrants (in dollars per share) | $ / shares														900
Series F Convertible Preferred Stock [Member] | March 2020 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share) | $ / shares													$ 900
Series F Convertible Preferred Stock [Member] | March 2021 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share) | $ / shares									$ 550
Exercise price of warrants (in dollars per share) | $ / shares									$ 550
Series F Convertible Preferred Stock [Member] | September 2021 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share) | $ / shares								$ 250
Exercise price of warrants (in dollars per share) | $ / shares								$ 250
Series F Convertible Preferred Stock [Member] | October 2022 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share) | $ / shares							$ 25												$ 250
Series F Convertible Preferred Stock [Member] | October 2023 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share) | $ / shares			$ 1.01
Series F Convertible Preferred Stock [Member] | Warrants to Purchase Common Stock [Member]
Class of Stock Disclosures [Abstract]
Warrants to purchase shares of common stock (in shares)																191
Series F Convertible Preferred Stock [Member] | Warrant Series 1 [Member]
Class of Stock Disclosures [Abstract]
Warrants to purchase shares of common stock (in shares)																16
Exercise price of warrants (in dollars per share) | $ / shares																$ 189,000
Series F Convertible Preferred Stock [Member] | Warrant Series 2 [Member]
Class of Stock Disclosures [Abstract]
Warrants to purchase shares of common stock (in shares)																4
Exercise price of warrants (in dollars per share) | $ / shares																$ 189,000
Series H Preferred Stock [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share) | $ / shares														$ 1,650
Maximum percentage of the applicable Unit offering price, by which exercise price can be lower than adjustment														10.00%
Series H Preferred Stock [Member] | January 2020 Offering [Member]
Class of Stock Disclosures [Abstract]
Issuance of common stock, net (in shares)														115,173
Series I Preferred Stock [Member]
Class of Stock Disclosures [Abstract]
Preferred stock issued (in shares)																	0	1,049,280
Preferred stock, shares outstanding (in shares)																	0	1,049,280
Preferred stock, par value (in dollars per share) | $ / shares																	$ 0.0001	$ 0.0001
Series I Preferred Stock [Member] | October 2022 Offering [Member]
Class of Stock Disclosures [Abstract]
Issuance of common stock, net (in shares)							23,157,124
Number of shares in one unit (in shares)							1
Class A Unit [Member] | October 2022 Offering [Member]
Class of Stock Disclosures [Abstract]
Issuance of common stock, net (in shares)							209,940
Common stock offering price per share (in dollars per share) | $ / shares							$ 25
Number of shares in one unit (in shares)							1
Common stock exercise price per share (in dollars per share) | $ / shares							$ 25
Class A Unit [Member] | Warrants [Member] | October 2022 Offering [Member]
Class of Stock Disclosures [Abstract]
Number of shares in one unit (in shares)							1.5
Class B Unit [Member] | October 2022 Offering [Member]
Class of Stock Disclosures [Abstract]
Issuance of common stock, net (in shares)							23,157,124
Common stock offering price per share (in dollars per share) | $ / shares							$ 0.25
Common stock exercise price per share (in dollars per share) | $ / shares							$ 0
Class B Unit [Member] | Warrants [Member] | October 2022 Offering [Member]
Class of Stock Disclosures [Abstract]
Number of shares in one unit (in shares)							1.5
Series J Convertible Preferred Stock [Member] | October 2023 Offering [Member]
Class of Stock Disclosures [Abstract]
Warrants to purchase shares of common stock (in shares)			0.5
Issuance of common stock, net (in shares)			150,000
Common stock offering price per share (in dollars per share) | $ / shares			$ 15
Number of shares in one unit (in shares)			1
Preferred stock, par value (in dollars per share) | $ / shares			$ 0.0001
Number of warrants included in each unit			1
Original issue discount percentage			40.00%
Additional shares issuable upon declaration of dividends (in shares)			362,933
Series J Convertible Preferred Stock [Member] | Common Stock [Member] | October 2023 Offering [Member]
Class of Stock Disclosures [Abstract]
Common stock, par value (in dollars per share) | $ / shares			$ 0.0001
Series J Convertible Preferred Stock [Member] | Warrants [Member] | October 2023 Offering [Member]
Class of Stock Disclosures [Abstract]
Warrants to purchase shares of common stock (in shares)	0.5
Exercise price of warrants (in dollars per share) | $ / shares	$ 7.5
Warrants term	3 years