Stockholders' Equity (Details)							9 Months Ended
	Sep. 17, 2021 USD ($) $ / shares shares	Mar. 19, 2021 USD ($) $ / shares shares	Oct. 09, 2020	Oct. 06, 2020	Mar. 12, 2019 $ / shares	Nov. 27, 2017 USD ($) $ / shares shares	Sep. 30, 2022 $ / shares shares	Dec. 31, 2021 shares	Mar. 23, 2020 $ / shares	Jan. 28, 2020 $ / shares	Nov. 06, 2019 $ / shares	Oct. 25, 2019 $ / shares	May 30, 2019 $ / shares shares	Jul. 03, 2018 $ / shares
Class of Stock Disclosures [Abstract]
Net proceeds from issuance of convertible preferred stock | $	$ 27,900,000
Preferred stock, shares outstanding (in shares) | shares							0	0
Reverse stock split			0.03
Minimum [Member]
Class of Stock Disclosures [Abstract]
Reverse stock split				0.2
Maximum [Member]
Class of Stock Disclosures [Abstract]
Reverse stock split				0.03
Expected Stock Price Volatility [Member]
Class of Stock Disclosures [Abstract]
Warrants measurement input							1.3621
January 2020 Offering [Member]
Class of Stock Disclosures [Abstract]
Exercise price of warrants (in dollars per share)							$ 2.5
March 2021 Offering [Member]
Class of Stock Disclosures [Abstract]
Issuance of common stock, net (in shares) | shares		3,795,816
Gross proceeds from public stock offering | $		$ 20,900,000
Net proceeds from public stock offering | $		$ 18,900,000
September 2021 Offering [Member]
Class of Stock Disclosures [Abstract]
Issuance of common stock, net (in shares) | shares	4,005,588
Gross proceeds from public stock offering | $	$ 10,000,000
Net proceeds from public stock offering | $	$ 9,000,000
Warrants to Purchase Common Stock [Member]
Class of Stock Disclosures [Abstract]
Number of warrants vested (in shares) | shares							0
Warrants to Purchase Common Stock [Member] | Consultant [Member]
Class of Stock Disclosures [Abstract]
Warrants to purchase shares of common stock (in shares) | shares													3,334
Exercise price of warrants (in dollars per share)							$ 57.9						$ 95.4
Series F Convertible Preferred Stock [Member]
Class of Stock Disclosures [Abstract]
Gross proceeds from issuance of convertible preferred stock | $						$ 18,000,000
Net proceeds from issuance of convertible preferred stock | $						$ 16,200,000
Conversion price (in dollars per share)						$ 1,890								$ 890.4
Number of consecutive trading days considered for expiration							20 days
Number of consecutive trading days							30 days
Preferred stock issued (in shares) | shares						18,000	127	127
Number of shares issuable on conversion of preferred stock (in shares) | shares						9,557
Preferred stock, shares outstanding (in shares) | shares							127	127
Aggregate cash placement fee					8.00%
Series F Convertible Preferred Stock [Member] | Minimum [Member]
Class of Stock Disclosures [Abstract]
Percentage of volume weighted average price of common stock						300.00%
Trading volume for each trading day | $						$ 200,000
Series F Convertible Preferred Stock [Member] | March 2019 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share)					$ 157.5
Series F Convertible Preferred Stock [Member] | October 2019 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share)												$ 42.3
Series F Convertible Preferred Stock [Member] | November 2019 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share)											$ 29.83
Series F Convertible Preferred Stock [Member] | January 2020 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share)										$ 16.5
Exercise price of warrants (in dollars per share)										$ 9
Series F Convertible Preferred Stock [Member] | March 2020 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share)									$ 9
Series F Convertible Preferred Stock [Member] | March 2021 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share)		$ 5.5
Exercise price of warrants (in dollars per share)		$ 5.5
Series F Convertible Preferred Stock [Member] | September 2021 Offering [Member]
Class of Stock Disclosures [Abstract]
Conversion price (in dollars per share)	$ 2.5
Exercise price of warrants (in dollars per share)	$ 2.5
Series F Convertible Preferred Stock [Member] | Warrants to Purchase Common Stock [Member]
Class of Stock Disclosures [Abstract]
Warrants to purchase shares of common stock (in shares) | shares						19,122
Series F Convertible Preferred Stock [Member] | Warrant Series 1 [Member]
Class of Stock Disclosures [Abstract]
Warrants to purchase shares of common stock (in shares) | shares						16
Exercise price of warrants (in dollars per share)						$ 1,890
Series F Convertible Preferred Stock [Member] | Warrant Series 2 [Member]
Class of Stock Disclosures [Abstract]
Warrants to purchase shares of common stock (in shares) | shares						16
Exercise price of warrants (in dollars per share)						$ 1,890