Nature of Business and Significant Accounting Policies, Loss Per Share (Details) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Loss per share [Abstract]
Net deemed dividends resulting from subsequent reduction in exercise price of warrants	$ 75,000	$ 200
Potential shares of common stock that are not included in the calculation of diluted net loss per share [Abstract]
Potential shares of common stock that are not included in the calculation of diluted net loss per share (in shares)	2,437,123	1,663,061
Reconciliation of reported net loss with reported net loss per share [Abstract]
Net loss	$ (19,578)	$ (15,836)
Deemed dividend to preferred shareholders (see Note 4)	(75)	(1,757)
Net loss after deemed dividend	$ (19,653)	$ (17,593)
Weighted average shares outstanding - basic (in shares)	6,852,000	1,649,000
Weighted average shares outstanding - diluted (in shares)	6,852,000	1,649,000
Basic loss per share (in dollars per share)	$ (2.87)	$ (10.67)
Diluted loss per share (in dollars per share)	$ (2.87)	$ (10.67)
Stock Options [Member]
Potential shares of common stock that are not included in the calculation of diluted net loss per share [Abstract]
Potential shares of common stock that are not included in the calculation of diluted net loss per share (in shares)	754,525	16,889
Warrants to Purchase Common Stock [Member]
Potential shares of common stock that are not included in the calculation of diluted net loss per share [Abstract]
Potential shares of common stock that are not included in the calculation of diluted net loss per share (in shares)	1,631,798	1,631,948
Series F Convertible Preferred Stock [Member]
Potential shares of common stock that are not included in the calculation of diluted net loss per share [Abstract]
Potential shares of common stock that are not included in the calculation of diluted net loss per share (in shares)	50,800	14,224