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Stock-Based Compensation, Stock Options (Details) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Stock-Based Compensation Expense Items [Abstract]    
Stock-based compensation expense $ 1,349 $ 1,512
Minimum [Member]    
Additional Disclosures [Abstract]    
Award vesting period 1 year  
Maximum [Member]    
Additional Disclosures [Abstract]    
Award vesting period 4 years  
Selling, General and Administrative [Member]    
Stock-Based Compensation Expense Items [Abstract]    
Stock-based compensation expense $ 1,252 1,387
Research and Development [Member]    
Stock-Based Compensation Expense Items [Abstract]    
Stock-based compensation expense $ 97 $ 125
Stock Options [Member]    
Stock Options Activity [Roll Forward]    
Outstanding, beginning balance (in shares) 13,471 4,638
Granted (in shares) 5,542 9,374
Exercised (in shares) 0 0
Forfeited/expired (in shares) (2,124) (541)
Outstanding, ending balance (in shares) 16,889 13,471
Vested at the end of the year (in shares) 7,254 2,383
Weighted Average Exercise Price [Abstract]    
Outstanding, beginning balance (in dollars per share) $ 515.33 $ 1,461.24
Granted (in dollars per share) 10.03 71.40
Exercised (in dollars per share) 0 0
Forfeited/expired (in dollars per share) 71.51 926.31
Outstanding, ending balance (in dollars per share) 405.34 515.33
Vested at the end of the year (in dollars per share) $ 697.37 $ 1,417.42
Weighted Average Remaining Contractual Term [Abstract]    
Options outstanding, weighted average remaining contractual life 8 years 5 months 19 days  
Options vested, weighted average remaining contractual life 8 years 25 days  
Aggregate Intrinsic Value [Abstract]    
Fair value of options, vested $ 1,700 $ 2,400
Weighted Average Assumptions used in Black-Scholes Option Pricing Model [Abstract]    
Expected dividend yield 0.00% 0.00%
Risk-free interest rate 0.65% 1.85%
Expected volatility 127.87% 121.67%
Expected life 5 years 10 months 28 days 6 years 2 months 19 days
Additional Disclosures [Abstract]    
Weighted-average fair value of options granted (in dollars per share) $ 8.79 $ 62.37
Total unrecognized compensation costs related to non-vested stock option awards $ 1,500  
Unrecognized compensation costs related to non-vested stock option awards, recognition period 2 years 6 months 11 days