Stock-Based Compensation, Stock Options and Restricted Stock Awards (Details) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018
Stock-Based Compensation Expense Items [Abstract]
Stock-based compensation expense	$ 1,512	$ 2,087
Minimum [Member]
Additional Disclosures [Abstract]
Award vesting period	1 year
Maximum [Member]
Additional Disclosures [Abstract]
Award vesting period	4 years
Selling, General and Administrative [Member]
Stock-Based Compensation Expense Items [Abstract]
Stock-based compensation expense	$ 1,387	1,958
Research and Development [Member]
Stock-Based Compensation Expense Items [Abstract]
Stock-based compensation expense	$ 125	$ 129
Stock Options [Member]
Stock Options Activity [Roll Forward]
Outstanding, beginning balance (in shares)	140,546	2,562
Granted (in shares)	281,834	163,997
Exercised (in shares)	0	0
Forfeited/expired (in shares)	(16,650)	(26,013)
Outstanding, ending balance (in shares)	405,730	140,546
Vested at the end of the year (in shares)	72,377	16,206
Weighted Average Exercise Price [Abstract]
Outstanding, beginning balance (in dollars per share)	$ 61.25	$ 1,049.93
Granted (in dollars per share)	2.38	45.76
Exercised (in dollars per share)	0	0
Forfeited/expired (in dollars per share)	31.77	61.01
Outstanding, ending balance (in dollars per share)	21.56	61.25
Vested at the end of the year (in dollars per share)	$ 74.21	$ 169.07
Weighted Average Remaining Contractual Term [Abstract]
Options outstanding, weighted average remaining contractual life	9 years 1 month 17 days
Options vested, weighted average remaining contractual life	8 years 2 months 5 days
Aggregate Intrinsic Value [Abstract]
Fair value of options, vested	$ 2,400	$ 900
Weighted Average Assumptions used in Black-Scholes Option Pricing Model [Abstract]
Expected dividend yield	0.00%	0.00%
Risk-free interest rate	1.85%	2.49%
Expected volatility	121.67%	120.54%
Expected life	6 years 2 months 19 days	6 years 2 months 23 days
Additional Disclosures [Abstract]
Weighted-average fair value of options granted (in dollars per share)	$ 2.07	$ 41.04
Total unrecognized compensation costs related to non-vested stock option awards	$ 2,900
Unrecognized compensation costs related to non-vested stock option awards, recognition period	3 years 2 months 12 days
Restricted Stock Units (RSU) [Member]
Restricted Stock Awards [Roll Forward]
Nonvested, beginning balance (in shares)	3	15
Granted (in shares)	0	0
Vested (in shares)	(3)	(12)
Forfeited (in shares)	0	0
Nonvested, ending balance (in shares)	0	3
Weighted Average Grant Price [Abstract]
Nonvested, beginning balance (in dollars per share)	$ 7,297.22	$ 7,297.22
Granted (in dollars per share)	0	0
Vested (in dollars per share)	7,297.22	7,297.22
Forfeited (in dollars per share)	0	0
Nonvested, ending balance (in dollars per share)	$ 0	$ 7,297.22