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Nature of Business and Basis of Presentation, Loss Per Share (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2019
Mar. 31, 2019
Jun. 30, 2018
Mar. 31, 2018
Jun. 30, 2019
Jun. 30, 2018
Dec. 31, 2018
Potential shares of common stock that are not included in the calculation of diluted net loss per share [Abstract]              
Potential shares of common stock that are not included in the calculation of diluted net loss per share (in shares)         6,325,383 781,678  
Reported net loss with reported net loss per share [Abstract]              
Net loss $ (4,430) $ (4,727) $ (4,181) $ (4,354) $ (9,157) $ (8,535)  
Deemed dividend to preferred shareholders (see Note 4)         (4,509)    
Net loss after deemed dividend $ (4,430)       $ (13,666)    
Weighted average shares outstanding (in shares) 2,295,000   321,000   1,550,000 304,000  
Basic and diluted loss per share (in dollars per share) $ (1.93)   $ (13.03)   $ (8.82) $ (28.03)  
New Accounting Pronouncement [Abstract]              
Operating lease right-of-use asset $ 531       $ 531   $ 0
Operating lease liability $ 533       $ 533    
Warrants to Purchase Common Stock [Member]              
Potential shares of common stock that are not included in the calculation of diluted net loss per share [Abstract]              
Potential shares of common stock that are not included in the calculation of diluted net loss per share (in shares)         5,430,721 608,787  
Series G Convertible Preferred Stock [Member]              
Potential shares of common stock that are not included in the calculation of diluted net loss per share [Abstract]              
Potential shares of common stock that are not included in the calculation of diluted net loss per share (in shares)         550,842 0  
Series F Convertible Preferred Stock [Member]              
Potential shares of common stock that are not included in the calculation of diluted net loss per share [Abstract]              
Potential shares of common stock that are not included in the calculation of diluted net loss per share (in shares)         102,185 20,740  
Stock Options [Member]              
Potential shares of common stock that are not included in the calculation of diluted net loss per share [Abstract]              
Potential shares of common stock that are not included in the calculation of diluted net loss per share (in shares)         241,635 152,142  
Restricted Stock Units [Member]              
Potential shares of common stock that are not included in the calculation of diluted net loss per share [Abstract]              
Potential shares of common stock that are not included in the calculation of diluted net loss per share (in shares)         0 9  
ASU 2016-02 [Member] | Adjustments Due to Adoption of ASU 2016-02 [Member]              
New Accounting Pronouncement [Abstract]              
Operating lease right-of-use asset             600
Operating lease liability             $ 600