Shareholder's Equity, Convertible Preferred Stock (Details) - USD ($)								12 Months Ended
	Nov. 27, 2017	Apr. 24, 2017	Jan. 10, 2017	Nov. 03, 2016	Oct. 30, 2016	Jul. 26, 2016	Jul. 20, 2016	Dec. 31, 2017	Dec. 31, 2016
Class of Stock [Line Items]
Proceeds from issuance of convertible preferred stock and Warrants					$ 3,800,000		$ 3,500,000
Net proceeds from issuance of convertible preferred stock	$ 16,200,000	$ 8,000,000
Preferred stock, shares outstanding (in shares)								0	0
Net deemed dividend								$ (11,590,000)	$ (1,900,000)
Common stock, shares issued (in shares)								3,798,929	38,862
Series B Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Preferred stock, shares issued (in shares)						3,468
Number of preferred shares converted to common stock (in shares)						6,149
Conversion price (in dollars per share)						$ 564.0
Proceed from issuance of preferred stock						$ 1,600,000
Series B-1 Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Preferred stock, shares issued (in shares)					2,227.2			0	1,824.4
Number of preferred shares converted to common stock (in shares)								17,866	3,948
Conversion price (in dollars per share)					$ 102
Number of convertible preferred shares converted (in shares)									402.8
Preferred stock, shares outstanding (in shares)								0	1,824.4
Series C Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Preferred stock, shares issued (in shares)				2,900				0	2,900
Number of preferred shares converted to common stock (in shares)									0
Conversion price (in dollars per share)				$ 102
Preferred stock, shares outstanding (in shares)								0	2,900
Beneficial conversion amount			$ 1,300,000
Series D Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Proceeds from issuance of convertible preferred stock and Warrants			$ 200,000
Preferred stock, shares issued (in shares)			200
Number of preferred shares converted to common stock (in shares)									0
Conversion price (in dollars per share)			$ 102	$ 102
Temporary stock, shares issued (in shares)				700				0	700
Beneficial conversion amount			$ 500,000
Temporary stock, shares outstanding (in shares)								0	700
Temporary equity								$ 0	$ 485,000
Series C and D Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Proceeds from issuance of convertible preferred stock and Warrants				$ 3,600,000
Number of preferred shares converted to common stock (in shares)								55,712
Temporary stock, shares outstanding (in shares)								0
Series B and B-1 Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Net deemed dividend								$ (1,900,000)	$ (1,900,000)
Series B, C And D Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Percentage of placement fee offered in cash								6.00%
Series E Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Preferred stock, shares issued (in shares)								6,400
Number of preferred shares converted to common stock (in shares)								320,000
Proceed from issuance of preferred stock		9,200,000
Net proceeds from issuance of convertible preferred stock		$ 8,000,000
Preferred stock, shares outstanding (in shares)								0
Beneficial conversion amount								$ 1,000,000
Percentage of placement fee offered in cash								9.00%
Net deemed dividend								$ (1,000,000)
Common stock, shares issued (in shares)								140,000
Series E Convertible Preferred Stock [Member] | Warrants [Member]
Class of Stock [Line Items]
Warrants to purchase shares of common stock (in shares)								640,000
Warrants issued to the placement agent (in shares)								0
Class A Units [Member]
Class of Stock [Line Items]
Public offering price (in dollars per share)								$ 20.00
Number of common stock (in shares)								1
Class A Units [Member] | Warrants [Member]
Class of Stock [Line Items]
Number of preferred shares converted to common stock (in shares)								1
Term of warrants								5 years
Number of warrants (in shares)								1
Exercise price of warrants (in dollars per share)								$ 22
Class B Units [Member]
Class of Stock [Line Items]
Number of preferred shares converted to common stock (in shares)								50
Public offering price (in dollars per share)								$ 1,000
Number of preferred stock per unit (in shares)								1
Class B Units [Member] | Warrants [Member]
Class of Stock [Line Items]
Warrants to purchase shares of common stock (in shares)								50
Exercise price of warrants (in dollars per share)								$ 22
Series F Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Preferred stock, shares issued (in shares)	18,000							3,780	0
Number of preferred shares converted to common stock (in shares)	4,000,000							3,171,060
Conversion price (in dollars per share)	$ 4.50
Number of convertible preferred shares converted (in shares)								14,220
Proceed from issuance of preferred stock	$ 18,000,000
Net proceeds from issuance of convertible preferred stock	16,200,000
Preferred stock, shares outstanding (in shares)								3,780	0
Beneficial conversion amount	$ 8,700,000
Percentage of placement fee offered in cash								8.00%
Net deemed dividend								$ (8,700,000)
Series F Convertible Preferred Stock [Member] | Warrants [Member]
Class of Stock [Line Items]
Warrants to purchase shares of common stock (in shares)	8,000,000
Warrants issued to the placement agent (in shares)								0
Series F Convertible Preferred Stock [Member] | Warrant Series 1 [Member]
Class of Stock [Line Items]
Number of preferred shares converted to common stock (in shares)	223
Exercise price of warrants (in dollars per share)	$ 4.50
Series F Convertible Preferred Stock [Member] | Warrant Series 2 [Member]
Class of Stock [Line Items]
Number of preferred shares converted to common stock (in shares)	223
Exercise price of warrants (in dollars per share)	$ 4.50