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Debt - Narrative (Details)
12 Months Ended 20 Months Ended
Nov. 30, 2020
USD ($)
Oct. 08, 2020
USD ($)
Sep. 30, 2020
USD ($)
Aug. 25, 2020
Jun. 22, 2016
USD ($)
Jun. 17, 2016
payment
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
prepayment
Dec. 31, 2020
USD ($)
May 31, 2019
amendment
May 01, 2020
USD ($)
Apr. 23, 2020
USD ($)
Debt Instrument [Line Items]                        
Number of times agreement was amended | amendment                   8    
Forgiveness amount threshold for PPP loan (not less than)                     $ 500,000  
Total revenues               $ 0 $ 10,006,000      
Other long-term liabilities               1,179,000 0      
Strategic Alliances and Collaborations                        
Debt Instrument [Line Items]                        
Total revenues               0 $ 10,000,000      
Strategic Alliances and Collaborations | Sanofi                        
Debt Instrument [Line Items]                        
Total revenues $ 5,000,000 $ 4,000,000 $ 1,000,000                  
Term Loan                        
Debt Instrument [Line Items]                        
Proceeds from borrowing under term loan         $ 20,000,000              
Stated interest rate, percentage           8.51%            
Number of monthly payments | payment           24            
Repayments of debt $ 5,000,000 $ 4,000,000 $ 1,000,000         $ 10,000,000        
Payment fee               5.50%        
Number of times agreement was amended | prepayment               3        
Additional extension for interest only payments               7 months        
Long-term debt               $ 4,681,000        
Other long-term liabilities               1,200,000        
Deferred finance costs               $ 100,000        
Debt instrument effective rate               8.98%        
Term Loan | Other Current Liabilities                        
Debt Instrument [Line Items]                        
Fee amount               $ 1,300,000        
Term Loan | London Interbank Offered Rate (LIBOR)                        
Debt Instrument [Line Items]                        
Basis spread on variable rate, percentage           0.44%            
PPP Loan                        
Debt Instrument [Line Items]                        
Debt instrument, face amount                     $ 700,000 $ 700,000
Tenth Amendment                        
Debt Instrument [Line Items]                        
Interest only payment extension       7 months                
Prepayment requirement       1000000000.00%                
Eleventh Amendment                        
Debt Instrument [Line Items]                        
Cash collateral for borrowed securities               5,000,000        
Fee amount               $ 300,000        
Eleventh Amendment | Forecast                        
Debt Instrument [Line Items]                        
Unrestricted net cash proceeds amount             $ 20,000,000