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Stockholders' Equity (Assumptions Used to Estimate Fair Value of Stock Options and Performance Stock and Employee Stock Purchase Plan) (Detail)
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Employee Stock Purchase Plan        
Weighted average assumptions        
Risk-free interest rate 1.00% 0.50% 0.80% 0.50%
Volatility 104.50% 94.50% 110.70% 85.40%
Dividend yield 0.00% 0.00% 0.00% 0.00%
Expected term (years) 6 months 6 months 6 months 6 months
Stock options        
Weighted average assumptions        
Risk-free interest rate 1.90% 1.50% 2.00% 1.40%
Volatility 89.50% 80.00% 89.40% 79.90%
Dividend yield 0.00% 0.00% 0.00% 0.00%
Expected term (years) 6 years 29 days 5 years 8 months 12 days 6 years 29 days 5 years 10 months 24 days
Performance stock options        
Weighted average assumptions        
Risk-free interest rate 0.00% 0.00% 2.10% 1.40%
Volatility 0.00% 0.00% 89.90% 79.30%
Dividend yield 0.00% 0.00% 0.00% 0.00%
Expected term (years) 0 years 0 years 5 years 7 months 21 days 6 years