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Related Party Transactions (Detail) - USD ($)
$ in Millions
1 Months Ended 3 Months Ended
Feb. 28, 2015
Mar. 31, 2016
Mar. 31, 2015
Sanofi      
Related Party Transaction [Line Items]      
Expenses incurred for services performed or out-of-pocket expenses under the Sanofi agreement   $ 0.8 $ 0.4
Alnylam      
Related Party Transaction [Line Items]      
Potential milestone payments to related party $ 33.0