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Stockholders' Equity (Common Stock Reserved for Future Issuance) (Detail) - shares
Mar. 31, 2016
Dec. 31, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Common stock options outstanding 6,624,083.000 5,126,000
Total common shares reserved for future issuance 11,394,504  
Common stock available for future grant under 2012 Equity Incentive Plan    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Common stock available for future grant 2,491,184  
Common stock available for future grant under 2015 Inducement Plan    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Common stock available for future grant 581,806  
Employee Stock Purchase Plan    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Common stock available for future grant 1,697,431