X0508 4 2024-01-18 0 0001505512 Regulus Therapeutics Inc. RGLS 0001762611 Aker Christopher Ray C/O REGULUS THERAPEUTICS INC. 4224 CAMPUS POINT COURT #210 SAN DIEGO CA 92121 0 1 0 0 Sr. VP & General Counsel 0 Common Stock 2024-01-18 4 S 0 5468 1.1906 D 10056 D The sales reported on this Form 4 represent shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of Restricted Stock Units (RSUs) received by the Reporting Person. These sales are made pursuant to an existing 10b5-1 plan under which the Reporting Person has irrevocably elected to satisfy the tax obligations through this sale and do not represent discretionary trades by the Reporting Person. Christopher Aker 2024-01-18